DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAMK2D and lok

DIOPT Version :9

Sequence 1:	NP_001308498.1	Gene:	CAMK2D / 817	HGNCID:	1462	Length:	533	Species:	Homo sapiens
Sequence 2:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster

Alignment Length:	349	Identity:	113/349 - (32%)
Similarity:	173/349 - (49%)	Gaps:	61/349 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLS-AR------DHQKLEREARICRLLKHP 71
            |.:..:||.||:.:||......|.|::|.||:....|| ||      |..::..||:|.:.|.||
  Fly   174 YYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHP 238

Human    72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRD 136
            .:||:||.:.:....|:|.:.:.||:|...|::.:..||..:.....|:..:|.:.|..||.|||
  Fly   239 CVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRD 303

Human   137 LKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMW 198
            |||:|:||.:..:...:|::||||:..||.| .......|||.|::||||   .::.|.|.||:|
  Fly   304 LKPDNVLLETNDEETLLKVSDFGLSKFVQKD-SVMRTLCGTPLYVAPEVLITGGREAYTKKVDIW 367

Human   199 ACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITA 263
            :.||:|:..|.|..||.||......||||.|.:.:..|.|.:|:..||.|||:||.::|.:|.:.
  Fly   368 SLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSI 432

Human   264 SEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVK 328
            .:.|:..|:..    |.|:.:                                ||.|:|. ||::
  Fly   433 DDVLQSSWLRD----APMLQK--------------------------------AKRLMKL-DGME 460

Human   329 INNKANVVTSPKENIPTPALEPQT 352
            |.         :||.    |||.|
  Fly   461 IE---------EENF----LEPPT 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAMK2D	NP_001308498.1	STKc_CaMKII	12..303	CDD:270988	100/298 (34%)
CAMK2D	NP_001308498.1	CaMKII_AD	380..507	CDD:285524
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	97/267 (36%)
		S_TKc	174..441	CDD:214567	97/267 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910