Protein Alignment CAMK2D and mek1

DIOPT Version :10

• Sequence 1: NP_001308498.1
• Gene: CAMK2D / 817
• HGNCID: 1462
• Length: 533
• Species: Homo sapiens
• Sequence 2: NP_594908.1
• Gene: mek1 / 2541604
• PomBaseID: SPAC14C4.03
• Length: 445
• Species: Schizosaccharomyces pombe
• Alignment Length: 310
• Identity: 106/310 - (34%)
• Similarity: 157/310 - (50%)
• Gaps: 35/310 - (11%)

Human     5 TTCTRFTDEY--QLF----EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSAR----DHQKLE 59
            ||...|..||  :.|    ..||.|.||.:...|...||.:||.|||:.||:|.:    ||
pombe   145 TTDNDFHHEYAGERFNITQRLLGIGGFSRIYMAMDNNTGGQYACKIIDKKKISTKRFFEDH---- 205

Human    60 REARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESV 124
             |..|.|.|.||||::::...:.|...::..::||||:||..:.......|......:.|||:.:
pombe   206 -EMTILRKLDHPNIIKVNMEYNSETQFFIFEEMVTGGDLFSYLTKLGTVPEVTTLFIMFQILQGL 269

Human   125 NHCHLNGIVHRDLKPENLLLASKSKGA-AVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR- 187
            .:.|...|:|||||.||:|:||.|... .:.|.|||:|..:|..::. ..|.|||.|.:||:.|
pombe   270 KYLHEQNIIHRDLKLENILIASSSDTIFRIILTDFGVARCMQKGKRL-STFVGTPEYTAPEIQRL 333

Human   188 ----------KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVT 242
                      ...|||.||:|:.|||:::||.|..|.:.:.       :|....||..|.|.:|:
pombe   334 KGRSQVEKENSSGYGKEVDLWSLGVIMFLLLSGNSPSFADG-------VKEKQVDFRDPVWKSVS 391

Human   243 PEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLK 292
            .:|||||:.:|..||..|.|..:.|.|||..:.|:..:.::....:..||
pombe   392 RQAKDLISNLLKTNPPDRFTVKQCLSHPWFARHSSRLTKLYETRILKPLK 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAMK2D	NP_001308498.1	STKc_CaMKII	12..303	CDD:270988	103/303 (34%)
		CaMKII_AD	380..507	CDD:285524
mek1	NP_594908.1	FHA_MEK1-like	40..143	CDD:438722
		STKc_CAMK	163..420	CDD:270687	95/269 (35%)