DRSC/TRiP Functional Genomics Resources

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Protein Alignment CAMK2D and srk1

DIOPT Version :10

Sequence 1:NP_001308498.1 Gene:CAMK2D / 817 HGNCID:1462 Length:533 Species:Homo sapiens
Sequence 2:NP_588136.1 Gene:srk1 / 2539027 PomBaseID:SPCC1322.08 Length:580 Species:Schizosaccharomyces pombe


Alignment Length:470 Identity:140/470 - (29%)
Similarity:211/470 - (44%) Gaps:112/470 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKII-----NTKKLSARDHQKLE-----REARICR 66
            ::|.|.:::|.||||.|.:.:...||::.|.|::     ||.....|..|.:|     :|.:|.|
pombe   122 EQYTLLQKMGDGAFSNVYKAIHNRTGEKVAIKVVQRAQPNTDPRDPRKRQGVESHNILKEVQIMR 186

Human    67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN- 130
            .:|||||::|.:.|....::|||.:|..|||||..||...|:||..:.|.|.|:..::.:.|.: 
pombe   187 RVKHPNIIQLLEFIQTPEYYYLVLELADGGELFHQIVRLTYFSEDLSRHVITQVAHAIRYLHEDC 251

Human   131 GIVHRDLKPENLLLAS--------------------------KSKGAA----VKLADFGLAIEVQ 165
            |:||||:||||||..|                          ...||.    ::||||||:    
pombe   252 GVVHRDIKPENLLFDSIDFVPSRVRKYRAGDDPDKVDEGEFIPGVGAGTIGRIRLADFGLS---- 312

Human   166 GDQQAWFGFAGTP----GYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQI 226
              :..|.....||    ||.:||::|.:.|.|.|||||.|.:||.:|.|:|||:||....|.:::
pombe   313 --KVVWDSHTQTPCGTMGYTAPEIVRDERYSKGVDMWALGCVLYTILCGFPPFYDESISLLTKKV 375

Human   227 KAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCL 291
            ..|.|.|.||.||.::..|||||:.:||::|..|....:.|.||||..        .|:.|....
pombe   376 SRGEYSFLSPWWDDISKSAKDLISHLLTVDPESRYDIHQFLAHPWISG--------SREPTFPAT 432

Human   292 KKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKANVVTSPKENIPTPALEPQTTVIH 356
            ...|..:: :.......|...:.:||.|..:.|.   :|:...|.     ||...|        |
pombe   433 DAPNTAQR-ENPFTYDFLEPEDVAAAGSAARTPG---VNSLREVF-----NISYAA--------H 480

Human   357 NPDGNKESTESSNTTIEDEDVKARKQ-------EIIKVTEQLIEAINNGDFEAYTKIC------- 407
            .              :|.|.::.|.|       ..:...:.|:|  .|.|::..||..       
pombe   481 R--------------MEQEKIRKRGQRGNQGIMNFMGDMDDLME--ENDDYDDGTKSVEHSMKRV 529

Human   408 ------DPGLTAFEP 416
                  ||.|.:.:|
pombe   530 NLSGENDPSLASRQP 544

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CAMK2DNP_001308498.1 STKc_CaMKII 12..303 CDD:270988 115/335 (34%)
CaMKII_AD 380..507 CDD:285524 12/57 (21%)
srk1NP_588136.1 STKc_RCK1-like 122..421 CDD:270998 110/304 (36%)

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