Protein Alignment CAMK2D and unc-43

DIOPT Version :10

• Sequence 1: NP_001308498.1
• Gene: CAMK2D / 817
• HGNCID: 1462
• Length: 533
• Species: Homo sapiens
• Sequence 2: NP_001255480.1
• Gene: unc-43 / 177921
• WormBaseID: WBGene00006779
• Length: 681
• Species: Caenorhabditis elegans
• Alignment Length: 570
• Identity: 342/570 - (60%)
• Similarity: 417/570 - (73%)
• Gaps: 67/570 - (11%)

Human     1 MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC 65
            :|.....|:|:|.|.:.||||||||||||||:...||.|:||||||||||||||.||||||||||
 Worm   109 LAMMNASTKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARIC 173

Human    66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 130
            |.|:|||||||||||.||.||||||||||||||||||||||:||||||||||||||||:.:||.|
 Worm   174 RKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN 238

Human   131 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPV 195
            |||||||||||||||||:|||||||||||||||| .|.:||.||||||||||||||:||||.|||
 Worm   239 GIVHRDLKPENLLLASKAKGAAVKLADFGLAIEV-NDSEAWHGFAGTPGYLSPEVLKKDPYSKPV 302

Human   196 DMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKR 260
            |:||||||||||||||||||||||||||.||||||||:|||||||||||||.||:.|||:||.||
 Worm   303 DIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKR 367

Human   261 ITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLK------------------------ 301
            |||.:|||.||||.|..|||.:|||:|||||||||||||||
 Worm   368 ITADQALKVPWICNRERVASAIHRQDTVDCLKKFNARRKLKAAISAVKMVTRMSGVLRTSDSTGS 432

Human   302 ---------------------------GAILTTMLATRNFS-AAKSLLKK-----PDGVKINNKA 333
                                       |||||||:||||.| ..::||.|     |..:|.::::
 Worm   433 VASNGSTTHDASQVAGTSSQPTSPAAEGAILTTMIATRNLSNLGRNLLNKKEQGPPSTIKESSES 497

Human   334 NVVTSPKENIPTPA-LEPQTTVIHNPDGNKESTESSNTTIEDE----DVKARKQEIIKVTEQLIE 393
            :......::..... |:.:.||: ..||......|||::...:    ::.|:||:|::||:.|::
 Worm   498 SQTIDDNDSEKGGGQLKHENTVV-RADGATGIVSSSNSSTASKSSSTNLSAQKQDIVRVTQTLLD 561

Human   394 AINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGD 458
            ||:..|||.||::||..:|.|||||||||:||::||||||:.  ::.|: :||.:|||:||::|:
 Worm   562 AISCKDFETYTRLCDTSMTCFEPEALGNLIEGIEFHRFYFDG--NRKNQ-VHTTMLNPNVHIIGE 623

Human   459 DAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPT 508
            ||||:||::|||::|.:|...|.||:|:|||.::.|:|..||.|||..|:
 Worm   624 DAACVAYVKLTQFLDRNGEAHTRQSQESRVWSKKQGRWVCVHVHRSTQPS 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAMK2D	NP_001308498.1	STKc_CaMKII	12..303	CDD:270988	245/341 (72%)
		CaMKII_AD	380..507	CDD:285524	67/126 (53%)
unc-43	NP_001255480.1	STKc_CaMKII	120..410	CDD:270988	245/290 (84%)
		CaMKII_AD	548..672	CDD:285524	67/126 (53%)