DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AT2G20650 and RNF38

DIOPT Version :9

Sequence 1:	NP_179657.2	Gene:	AT2G20650 / 816593	AraportID:	AT2G20650	Length:	559	Species:	Arabidopsis thaliana
Sequence 2:	NP_073618.3	Gene:	RNF38 / 152006	HGNCID:	18052	Length:	515	Species:	Homo sapiens

Alignment Length:	146	Identity:	42/146 - (28%)
Similarity:	57/146 - (39%)	Gaps:	37/146 - (25%)

- Green bases have known domain annotations that are detailed below.

plant   421 PLHPY---YILGMTVTRLAI-PLYVFGCPKNFMRVEPSKAWCVSLCAFMGFQAGVLLLQHYFGSR 481
            |.||.   |:|.|.....|: |.:.|........||..:|              :|.|....|..
Human   383 PYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEA--------------LLNLAERLGEA 433

plant   482 CFVPRKL-------LPEKYSYYRRLDHNVNRSRD--CVICMTTIDLRHRINDCMVTPCEHIFHSG 537
              .||.|       ||   ||  |.:.|.::|..  ||:||...:.|..:.   |.||.|.||:.
Human   434 --KPRGLTKADIEQLP---SY--RFNPNNHQSEQTLCVVCMCDFESRQLLR---VLPCNHEFHAK 488

plant   538 CLQRWMDIKMECPTCR 553
            |:.:|:.....||.||
Human   489 CVDKWLKANRTCPICR 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AT2G20650	NP_179657.2	DUF2921	<405..483	CDD:402626	15/65 (23%)
AT2G20650	NP_179657.2	COG5540	<508..558	CDD:227827	17/48 (35%)
RNF38	NP_073618.3	Bipartite nuclear localization signal 1	57..71
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..141
		Bipartite nuclear localization signal 2	115..131
		RING-H2_RNF38_like	460..504	CDD:319386	15/46 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910