Protein Alignment DIAPH3 and Diaph3

DIOPT Version :10

• Sequence 1: NP_001035982.1
• Gene: DIAPH3 / 81624
• HGNCID: 15480
• Length: 1193
• Species: Homo sapiens
• Sequence 2: NP_062644.1
• Gene: Diaph3 / 56419
• MGIID: 1927222
• Length: 1171
• Species: Mus musculus
• Alignment Length: 1194
• Identity: 996/1194 - (83%)
• Similarity: 1069/1194 - (89%)
• Gaps: 24/1194 - (2%)

Human     1 MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPEEPGEKRPKFHLNIR 65
            ||||:.|        |.|            |:||..||||.| ..||:||.||||||||.|||||
Mouse     1 MERHRAR--------ALG------------RDSKSSRRKGLQ-SAPPAGPYEPGEKRPKLHLNIR 44

Human    66 TLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASSDCSAAPLEMMENFPKPLSENELLELFEKMM 130
            ||||||||||||||||||||||||||:|||....||.|:...|.|||.||.|.|:|:|:||||||
Mouse    45 TLTDDMLDKFASIRIPGSKKERPPLPHLKTVSGISDSSSLSSETMENNPKALPESEVLKLFEKMM 109

Human   131 EDMNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLKRSRQISPQEFIHELKMGSADERLVTC 195
            ||||||||||||||||||.|||||||||||||||||||:.|||||||||:||||||..||||.|.
Mouse   110 EDMNLNEDKKAPLREKDFGIKKEMVMQYINTASKTGSLRSSRQISPQEFLHELKMGYTDERLFTY 174

Human   196 LESLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGL 260
            ||||||||||:|||||:||||||||||||||||||:|:||||||||.||||||||:|||||||||
Mouse   175 LESLRVSLTSHPVSWVQSFGHEGLGLLLDILEKLINGQIQEKVVKKTQHKVIQCLRALMNTQYGL 239

Human   261 ERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRFFC 325
            |||||::|||||||||:|||.|.||.|||||||||||||||||||||||||||||||:||||||.
Mouse   240 ERIMSDKRSLSLLAKAMDPRQPAMMADVVKLLSAVCIVGEESILEEVLEALTSAGEERKIDRFFS 304

Human   326 IVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLK 390
            ||||||||||.||||||||||||||||||||||||:|||||||||||||||||.|||||||||||
Mouse   305 IVEGLRHNSVNLQVACMQLINALVTSPDDLDFRLHLRNEFMRCGLKEILPNLKGIKNDGLDIQLK 369

Human   391 VFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQ 455
            ||||||||||.|..|||||||||||||.|||:|:|.|||||||||:|:||||||||||||.|||:
Mouse   370 VFDEHKEEDLSEFFHRLEDIRAELDEASDVYSMLWDTVKETRAEGHFLSILQHLLLIRNDRFIRE 434

Human   456 QYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFEEKASELYKKFEKEF 520
            |||||||||||||||||||.||||||||||||||:||||:|||||||:|:||||||..||||||.
Mouse   435 QYFKLIDECVSQIVLHRDGTDPDFTYRKRLDLDLSQFVDVCIDQAKLDEWEEKASEHCKKFEKEC 499

Human   521 TDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSGG 585
            ||||||||:|||:||||||||||||||||||||||....|||.||.||..|.|||||.||..|||
Mouse   500 TDHQETQAQLQKREAKINELQAELQAFKSQFGALPPGTKIPLQPSVEGEAGPSALPPAPPALSGG 564

Human   586 -GVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRL 649
             ..|||||||||||||||.|||.|||||||||||||||:|.||. ||||||||||||||||||||
Mouse   565 VPPPPPPPPPPPPPLPGMPMPFGGPVPPPPPLGFLGGQSSIPLN-LPFGLKPKKEFKPEISMRRL 628

Human   650 NWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKF 714
            |||||.|:||:|||||||||||||||.|||||||||||||:||:|...|.:|||.|||::|||||
Mouse   629 NWLKIGPNEMSENCFWIKVNENKYENRDLLCKLENTFCCQEKEKRNTNDFDEKKVIKKRMKELKF 693

Human   715 LDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSN 779
            ||.||||||||||||||||||:||.||||||||:|:|||||||||||||:|||.|||||:|:|::
Mouse   694 LDPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNLIKHLPDEEQLKSLSQFRSDYNS 758

Human   780 LCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVL 844
            |||||||.|||||||||||||||||||||||||||||||||||||||||||||||.|||||||||
Mouse   759 LCEPEQFAVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKGFSKLLELVL 823

Human   845 LMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDK 909
            ||||||||||||||||||:||||||||||||||||||||||||::||||:.|||:|||||..|||
Mouse   824 LMGNYMNAGSRNAQTFGFDLSSLCKLKDTKSADQKTTLLHFLVDVCEEKHADILHFVDDLAHLDK 888

Human   910 ASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENM 974
            ||:||||.||||::|||||||||||.|||||||||||||||.|||.|||||.||||.||.|..:|
Mouse   889 ASRVSVEMLEKNVKQMGRQLQQLEKNLETFPPPEDLHDKFVIKMSSFVISANEQYEKLSTLLGSM 953

Human   975 EKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERER 1039
            .:|||||:||||:|:||||||:|..|||||||:||.|:|||||||||.|||||.|||||.||:||
Mouse   954 TQLYQSIMGYYAVDMKKVSVEEFFNDLNNFRTSFMLALKENIKKREAAEKEKRARIAKERAEKER 1018

Human  1040 LERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVC 1104
            |||||:||||||||||||||||||:|||||||||||||||||||..||:||||||||||||||||
Mouse  1019 LERQQEKKRLLEMKTEGDETGVMDSLLEALQSGAAFRDRRKRTPKLKDIRQSLSPMSQRPVLKVC 1083

Human  1105 NHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVESNRKKETE 1169
            ||||||:|||||||.|::|||||||||||||||||||||.|||||||.| |||||.|||:|||.|
Mouse  1084 NHENQKMQLTEGSRPHHSINCNSTRTPVAKELNYNLDTHASTGRIKAVE-KEACNAESNKKKEME 1147

Human  1170 LLGSFSKNESVPEVEALLARLRAL 1193
            ||||.:|:||||||||||||||||
Mouse  1148 LLGSVAKSESVPEVEALLARLRAL 1171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIAPH3	NP_001035982.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57		23/55 (42%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9Z207	36..60		16/23 (70%)
		Drf_GBD	114..297	CDD:461886	157/182 (86%)
		Drf_FH3	305..488	CDD:461885	165/182 (91%)
		CwlO1	499..>552	CDD:443091	45/52 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	558..622		49/64 (77%)
		FH2	636..1008	CDD:396655	315/371 (85%)
		Nuclear export signal. /evidence=ECO:0000250|UniProtKB:Q9Z207	1184..1193		8/8 (100%)
Diaph3	NP_062644.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		27/59 (46%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:19117945	16..39		16/23 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..95		22/34 (65%)
		Drf_GBD	96..276	CDD:461886	155/179 (87%)
		Drf_FH3	284..471	CDD:461885	168/186 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..601		51/68 (75%)
		FH2	615..987	CDD:396655	315/371 (85%)
		Casc1_N	999..>1061	CDD:464947	55/61 (90%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:19117945	1162..1171		8/8 (100%)