Protein Alignment DIAPH3 and diaph3

DIOPT Version :10

• Sequence 1: NP_001035982.1
• Gene: DIAPH3 / 81624
• HGNCID: 15480
• Length: 1193
• Species: Homo sapiens
• Sequence 2: NP_001003624.1
• Gene: diaph3 / 445230
• ZFINID: ZDB-GENE-040801-144
• Length: 267
• Species: Danio rerio
• Alignment Length: 276
• Identity: 149/276 - (53%)
• Similarity: 181/276 - (65%)
• Gaps: 33/276 - (11%)

Human     5 QPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPE--EPGEKRPKFHLNIRTL 67
            |||....:||                ||:|..|:||........|..  :.|||:|||
Zfish     6 QPRYEGSSQG----------------RENKFNRKKGFGAGVSSQGGSSGDDGEKKPKF------- 47

Human    68 TDDMLDKFASIRIPGSKKERPPLPNLKTAFASSDCSAAPLEMMENFPKPLSENELLELFEKMMED 132
                ||:|:||||||||||||.|.::....:|.|.|::. |..|...:..||.|:|.||||||||
Zfish    48 ----LDRFSSIRIPGSKKERPNLSHMSKHSSSGDWSSSS-EFEELSSRITSEKEILALFEKMMED 107

Human   133 MNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLKRSRQISPQEFIHELKMGSADERLVTCLE 197
            |||||:|||||||||.:.|:|||:|||.||:|||||:.|.|||||||:.|||.|:.||||..||:
Zfish   108 MNLNEEKKAPLREKDLNTKREMVLQYIVTAAKTGSLRSSSQISPQEFLSELKSGATDERLFACLD 172

Human   198 SLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGLE- 261
            ||||||||||||||:||||||||||||.||||:..|.||||.||:||||||||||.||.:....
Zfish   173 SLRVSLTSNPVSWVQSFGHEGLGLLLDTLEKLLLKKHQEKVDKKSQHKVIQCLKAFMNNKVITSP 237

Human   262 --RIMSEERSLSLLAK 275
              |:.|....:.:::|
Zfish   238 SCRVSSSSHLIIVISK 253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIAPH3	NP_001035982.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57		14/53 (26%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9Z207	36..60		8/25 (32%)
		Drf_GBD	114..297	CDD:461886	110/165 (67%)
		Drf_FH3	305..488	CDD:461885
		CwlO1	499..>552	CDD:443091
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	558..622
		FH2	636..1008	CDD:396655
		Nuclear export signal. /evidence=ECO:0000250|UniProtKB:Q9Z207	1184..1193
diaph3	NP_001003624.1	Drf_GBD	93..>233	CDD:461886	107/139 (77%)