Protein Alignment DIAPH3 and cyk-1

DIOPT Version :10

• Sequence 1: NP_001035982.1
• Gene: DIAPH3 / 81624
• HGNCID: 15480
• Length: 1193
• Species: Homo sapiens
• Sequence 2: NP_741211.3
• Gene: cyk-1 / 175983
• WormBaseID: WBGene00000872
• Length: 1437
• Species: Caenorhabditis elegans
• Alignment Length: 1377
• Identity: 345/1377 - (25%)
• Similarity: 594/1377 - (43%)
• Gaps: 268/1377 - (19%)

Human    34 KMPRRKGPQHPPPPSGPEEPGEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKERPPLPNL-KTAF 97
            |..||...:| ...:|..:...:|..|||:....:....|.|:|.|.  .:|:|..|.|: .:::
 Worm   106 KFKRRSAERH-SMLAGAADFASRRSPFHLSGANGSGRWTDLFSSSRF--KRKQRQKLNNVPSSSY 167

Human    98 ASSD------------CSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKK----APL--- 143
            :::|            .|.|.....|:|....:|:|:.|.|.|:|.|..|.|..|    .||
 Worm   168 SNNDYGTYAGTQSIGGFSIASNSSGESFALSGTEDEIREEFRKIMLDKGLPEADKIISNTPLDQM 232

Human   144 -------REKDFSIK---KEMVMQYINTASKTGSLKRSRQISPQEFIHELKMGSADERLVTCLES 198
                   |::|...|   .|.|::.:....||.::...:|                 .:||
 Worm   233 KMMIENSRKQDNQAKGRSPEWVVRVLGEILKTKNIPECKQ-----------------DIVT---- 276

Human   199 LRVSLTSNPVSWVESF--------GHEGLGLLLD----ILEKLISGKIQEK----VVKKNQHKVI 247
            :||.|....||::..|        |..|..|:..    :|::|.|.::..|    ::...| :::
 Worm   277 VRVQLVGQGVSFLNKFAVEVHDESGRTGADLICCLYSLVLKRLRSSEVGSKYELDLIDFLQ-EIV 340

Human   248 QCLKALMNTQYGLERIMSEERSL-SLLAK---AVDPRHPN---------MMTDVVK--------- 290
            :|::.|:||..||..::.....: |||.:   .::.|..|         :..|||:
 Worm   341 RCVRTLINTHVGLVLVLRRNSPVYSLLIQTLCVLNRREQNDHEAAEIRAIRVDVVRTCYTLIFVQ 405

Human   291 ---LLSAVCIVGEESILEEVLEALTSAGEEKK----IDRF---FCIVEGLRHNSVQLQVACMQLI 345
               |.:.:.:.|::.:..|:  :|.:..|.|:    :.||   ...::.|.....:..:..:.:|
 Worm   406 HDTLSTPIEMTGQQKMFMEL--SLIAKAESKRLNEPVSRFRPLISCIDFLESRDPKQGMYVLLMI 468

Human   346 NALVT------SPDDL-------DFRLHIRNEFMRCGLKEILPNL---KCIKNDGLDIQLKVFDE 394
            |.::.      |.|.:       ..|:.:|:|..:..|.:.:...   :.:.:...|:...:..|
 Worm   469 NMMINGVDRNISDDQMWTEETMWQARMRLRSEAAKDKLHKYIEKFTTSETVNSQIRDVAQNMLTE 533

Human   395 HKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFK 459
            | ..||..|..:||:::.|.|.....:.::.:..:.|..|...:||||.:.|...|...::.|.|
 Worm   534 H-NADLETLMGKLENVKGEYDTLDGCFELLAANSEATGTETVLLSILQLMTLTNEDMSTKRSYMK 597

Human   460 LIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEF------EEKASELYKKFEK 518
            ||:..:|.|:|||..:||...|:...::.:.:.:|...|:...::.      :::|..:..::.|
 Worm   598 LIETAISDILLHRTPIDPQADYKFVFEVPVAEIIDKMQDEEMAKKVRQATSAKQEAVAMQGEYWK 662

Human   519 EFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPP----PP 579
            ...|.|:...||:|   .||:.:..|..        |...|:..|.:..||:  |||||    ||
 Worm   663 TLCDFQKEAEELRK---HINDPKIPLPP--------PTKMNLSAPSTSAGGS--SALPPITGGPP 714

Human   580 PLPS----GGGVPPPPPP---------PPPPPLPGMRMPFSG--------------PVPPPPPLG 617
            |.|.    .||.||||||         |||||.||...|.||              |.|||||.|
 Worm   715 PPPGLPPITGGPPPPPPPGGLPPITGGPPPPPPPGGLPPISGGPPPPPPPPGGCPPPPPPPPPGG 779

Human   618 FLGGQNSPP--------LPILPFGLKPKKEFKPEISMRRLNW--LKIRPHEMTENCFWIKVNENK 672
            |.||...||        .|::|..|.|||..|.:..||:..|  ..|.|.::....||:..||.:
 Worm   780 FKGGPPPPPPPGMFAPMAPVIPDYLPPKKVPKVDGPMRKFPWGAHTINPRDIPRESFWVGTNEEQ 844

Human   673 YENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFL-DSKIAQNLSIFLSSFRVPYEE 736
            ..:..:..:|...|.  .|.......:....:.|||:|..:.: |.|:.|.|.|...|.::.:.|
 Worm   845 LTSDRMFDRLRTKFA--TKPAANSGTLGGVLNSKKKVKTAQVIHDDKLLQKLGILQGSIKMSHSE 907

Human   737 IRMMILEVDETRLAESMIQNLIKHLP-DQEQLNSLSQF-KSEYSNLCEPEQFVVVMSNVKRLRPR 799
            :::.||||:|..|....::.|...:| ::|.::.|... |:::..:.|.||||..:..::.|..|
 Worm   908 LKLAILEVNEKVLTVGFLEQLRSAMPVEKELIDKLRAVNKAQFEEMPEGEQFVTRLLQIQGLPLR 972

Human   800 LSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRN-AQTFGFN 863
            |..:|||::|.|.:|.:||.:.:|..||||::.|:.|...|:|||..||:|...::| :..:.|:
 Worm   973 LDLVLFKMRFSEVLNELKPAMSSVMEACEEVRASEGFRTFLKLVLATGNFMGGATKNYSSAYAFD 1037

Human   864 LSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNF-VDDLEPLDKASKVSVETLEKNLRQMGR 927
            :..|.:|.|||..|.:.||||.|:|..:...|....| :.|.....::|:|:.:.:.|.::....
 Worm  1038 MRMLTRLVDTKDVDNRHTLLHHLIEEMKRIDPRRARFALTDFHHCIESSRVNADEIRKTVQLTEN 1102

Human   928 QLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKV 992
            .:::||..|:.:....: .|.|..||..|...|.:::.|:|.:...|:..::|::.|||.:.||.
 Worm  1103 NIKKLENCLKVYKIQGE-RDLFDEKMRPFHEKAVKEFSTVSSMCGKMKNDWESLVKYYAFNDKKY 1166

Human   993 SVEDFLTDLNNFRTTFMQAIKE-----NIKKREAE-EKEKRVRIAKELAERERLERQQKKKR--- 1048
            .:|:|..|:..|...:..|.||     ..|::||| |.:||.::.:...||:.|:.:|...|
 Worm  1167 PMEEFFADIRTFSEQYSNAWKELDAEAEAKRKEAEFETQKRKQLQQSQQERKPLQERQAINRVPR 1231

Human  1049 ----LLEMKTEGDETGVMDNL---------LEALQSGAAFRDRRKRTPMPKDVR----------- 1089
                ::.:.|..|:.||:|.|         |:.|.|  |...|..|:.:|...|
 Worm  1232 TPAAMIRVSTAADKAGVLDELERATGNADFLQTLMS--ATNSRTPRSGLPARTRGGGRLGGGLDR 1294

Human  1090 ------------QSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPV-----AKELN 1137
                        |.|:..:..|||......::.|...:..|.  |:...|:..|.     ||...
 Worm  1295 QRSRHQNALGQLQDLTGCASEPVLSGQFARSRNVPQNDLQRQ--NMELPSSVKPTTALDRAKAFG 1357

Human  1138 YNLDTHTSTGRIKAAEKKE----ACNVE-----SNRKKETELLGSFSKNES-------------- 1179
            ..|....:..:::...|.:    ..|:.     |...||.:..||.|.:..
 Worm  1358 VGLPIGQNELKVRVRRKGQPAVPVTNINGTSQISPTHKENDPTGSSSTSSGPASSNTATSSSSGT 1422

Human  1180 -VPEVEALLARL 1190
             ||..:.|||||
 Worm  1423 VVPSTDDLLARL 1434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIAPH3	NP_001035982.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57		5/22 (23%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9Z207	36..60		5/23 (22%)
		Drf_GBD	114..297	CDD:461886	51/240 (21%)
		Drf_FH3	305..488	CDD:461885	45/205 (22%)
		CwlO1	499..>552	CDD:443091	10/58 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	558..622		40/94 (43%)
		FH2	636..1008	CDD:396655	110/378 (29%)
		Nuclear export signal. /evidence=ECO:0000250|UniProtKB:Q9Z207	1184..1193		5/7 (71%)
cyk-1	NP_741211.3	Drf_GBD	201..387	CDD:461886	47/207 (23%)
		Drf_FH3	422..630	CDD:461885	45/210 (21%)
		FH2	807..1257	CDD:214697	130/452 (29%)