Protein Alignment NECTIN4 and nectin4a

DIOPT Version :9

• Sequence 1: XP_011508323.1
• Gene: NECTIN4 / 81607
• HGNCID: 19688
• Length: 511
• Species: Homo sapiens
• Sequence 2: XP_689011.4
• Gene: nectin4a / 560512
• ZFINID: ZDB-GENE-160728-55
• Length: 629
• Species: Danio rerio
• Alignment Length: 607
• Identity: 178/607 - (29%)
• Similarity: 264/607 - (43%)
• Gaps: 153/607 - (25%)

Human    31 AGELETS---------DVVTVVLGQDAKLPC-FYRGDSGEQVGQVAWARVDAGEGAQELALLHSK 85
            :||.|.|         |:.::..| :.:||| |...||...|.||.|.|.:.|. .:::...|.|
Zfish    22 SGEEEYSFLEPSESPWDLWSLAEG-ETRLPCRFNVSDSEITVVQVLWIRENNGV-EEQILTAHFK 84

Human    86 YG---LHVSPAYEGRVEQPPPPRNPL-DGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVL 146
            .|   .|.|  |.|||..  ...||: |.::::...:.||||:|:|::.|||:|:|:|.:.|.|.
Zfish    85 EGQTEFHSS--YSGRVRF--ETNNPIADSALIIMRTLSADEGKYKCKIITFPSGNFEAEIVLTVW 145

Human   147 VPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLV 211
            ..|:.||. ...|.|||....||||.|...|...::||||:.|.:.::|...|.|:.   :|.|.
Zfish   146 TKPISSLK-SYTLIEGQSFRPAASCRAMAKPVAGLSWDTELPGQSQNQSSDESVSSI---KFSLH 206

Human   212 PSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQP 276
            |.||||||.|.|:|.||.....:||::.|.|.:...|.:.|.:|.  |....:||.|:|..||.|
Zfish   207 PYRSMNGQKLDCLVWHPSQKGPERISNKLIVHYPPNAVISGYKDD--WFAEMQGATLQCSGEGNP 269

Human   277 PPS-YNWTRLDGPLPSGVRVDGDTLGFP-PLTTEHSGIYVCHVSNEFSSRDSQVTVDVLADPQED 339
            .|. :||||.||.||.||.|||.||.|. ||.....|.|:|..:|...|..:::.|.: ::|..
Zfish   270 KPHLFNWTRKDGALPEGVIVDGGTLLFSRPLRLADKGHYICTTTNLVGSGKTEIEVKI-SEPTP- 332

Human   340 SGKQVDLVSASVVVVGVIAAL---LFCLLVVVVVLMSRYHRRKAQQMTQKYEEEL----TLTREN 397
                 .:.|.:.:::..||||   :...|:.|::.::|:::||..|:..:.:|:.    ||:|:.
Zfish   333 -----PIASVNFMLMITIAALAAGVVLTLIGVIICVNRHYKRKNNQLAIELDEKKVEINTLSRQA 392

Human   398 SIRRLHSHHTDPRSQPEESVGLRAEG----------HPDSLKDNSSCSVMSEEPEGRSYSTLTTV 452
            |.||::|..||.| ..|::..||.||          .|.|....|:...:........|:|....
Zfish   393 SFRRVNSSSTDNR-YSEDNHPLRVEGTIRTSLSSLDRPRSRDSRSTLGGVDSLGRPAIYNTSRRG 456

Human   453 RE-----------------------IETQTELLSP------------------------------ 464
            ||                       :..:|.||.|
Zfish   457 REKTIDRADRESARLMMESFEQDSNMSQETHLLPPLHPSSYTMDQPADMVRSRNGNAILPAEGRP 521

Human   465 --------GSGR------------AEEEEDQ----DEG----------------------IKQAM 483
                    ||.|            .:|||..    |.|                      |.:|:
Zfish   522 HSGGSTRGGSSRHHSPLVTMYPTLTDEEEGSVSPTDSGVHRGTLEHDAFENGDSETTSSQISEAL 586

Human   484 -NHFVQENGTLRAKPTGNGIYI 504
             :||.:.|||||.|...|.|.:
Zfish   587 SSHFERTNGTLRPKVKPNNIIL 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NECTIN4	XP_011508323.1	IG_like	37..145	CDD:214653	40/121 (33%)
		Ig1_Nectin-4_like	46..146	CDD:143296	37/104 (36%)
		Ig2_Nectin-3-4_like	149..242	CDD:143328	38/92 (41%)
		IG_like	259..332	CDD:214653	33/74 (45%)
		IGc2	268..320	CDD:197706	27/53 (51%)
nectin4a	XP_689011.4	IG_like	44..144	CDD:214653	38/105 (36%)
		Ig	45..145	CDD:299845	38/105 (36%)
		Ig	154..237	CDD:299845	35/85 (41%)
		Ig	260..325	CDD:299845	29/64 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194341346
Domainoid	1	1.000	67	1.000	Domainoid score	I32457
eggNOG	1	0.900	-	-		E1_2CRXB
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32744
Inparanoid	1	1.050	217	1.000	Inparanoid score	I10770
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237316at33208
OrthoFinder	1	1.000	-	-		FOG0003314
OrthoInspector	1	1.000	-	-		otm27040
orthoMCL	1	0.900	-	-		OOG6_117588
Panther	1	1.100	-	-	LDO	PTHR23277
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7662
SonicParanoid	1	1.000	-	-		X5723
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790