Protein Alignment CAMK2B and camk2b1

DIOPT Version :10

• Sequence 1: XP_011513849.1
• Gene: CAMK2B / 816
• HGNCID: 1461
• Length: 709
• Species: Homo sapiens
• Sequence 2: XP_021331894.1
• Gene: camk2b1 / 562064
• ZFINID: ZDB-GENE-030131-9588
• Length: 693
• Species: Danio rerio
• Alignment Length: 745
• Identity: 542/745 - (72%)
• Similarity: 584/745 - (78%)
• Gaps: 88/745 - (11%)

Human     1 MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARIC 65
            |||| |||||||||||||::||||||||||||||.||.|||||||||||||||||||||||||||
Zfish     1 MATT-TCTRFTDEYQLYEELGKGAFSVVRRCVKLSTGQEYAAKIINTKKLSARDHQKLEREARIC 64

Human    66 RLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 130
            |||||.|||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||
Zfish    65 RLLKHPNIVRLHDSISEEGFHYLLFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 129

Human   131 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPV 195
            |||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||
Zfish   130 GVVHRDLKPENLLLASKCKNAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPV 194

Human   196 DIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKR 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   195 DIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKR 259

Human   261 ITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVG-RQTTAPA 324
            |||.|||||||||||||||||||||||||||||||||||||||||||||.:|||||| |||||||
Zfish   260 ITAQEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLVSRNFSVGSRQTTAPA 324

Human   325 TMS------TAASGTTMGLVEQ-AKSLLNKKADGVK----------PQTNSTKNSAAATSPKGTL 372
            :::      .||:|||.||||| ||:|||||||..|          ||||||||| ..|||||.|
Zfish   325 SVTAAAAAVAAAAGTTAGLVEQAAKTLLNKKADVKKRKSSSTIQYMPQTNSTKNS-IVTSPKGNL 388

Human   373 PPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVRRGSGAPEAEGPLPCPSP 437
            |..|||.|||||||.||||||||||:|.|:|||:.|...|.:  |||:....||:     |.|:.
Zfish   389 PSPALEAQTTVIHNAVDGIKESSDSSNATVEDEEMKGKVVDN--SSVQSNPSAPQ-----PDPTH 446

Human   438 APFSPLPA--PSPRISDILNSVRRGS-GTPEAEGPLSAGPPPCLSPALLGPLSSPS--PRISDIL 497
            .|..|.||  .:.:.:|:|..||||| .|.:|||..:..|....:|:.....|.|:  .|::|::
Zfish   447 TPQGPAPAVFTATKFTDLLGVVRRGSVPTSDAEGGTTTTPAVVAAPSTPQTPSIPTQMSRLTDLV 511

Human   498 NSVRRGSGTPEAEG-PS------------PVGPPPCPSPTIPGPLPTPWMDDIPGLLPPPPVGRH 549
            :||||.: .|:.:. ||            |..|.|.|:.....|||:
Zfish   512 SSVRRPT-VPQTDSEPSAASRALSPPVSVPSHPSPSPAQVSSSPLPS------------------ 557

Human   550 QTGGGVEILLEKRLLGHGLGMAGQWLARKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPE 614
                           .|         :|||||||.|||||||:|||||||||||||||||.||||
Zfish   558 ---------------AH---------SRKQEIIKITEQLIEAINNGDFEAYAKICDPGLTCFEPE 598

Human   615 ALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQ 679
            ||||||||||||||||||||:||||||||||||||||:|||:||||||||||||:|||||||:||
Zfish   599 ALGNLVEGMDFHRFYFENLLSKNSKPIHTTILNPHVHLIGEEAACIAYIRLTQYVDGQGRPRSSQ 663

Human   680 SEETRVWHRRDGKWQNVHFHCSGAPVAPLQ 709
            |||||||||||.|||||||||||||.||||
Zfish   664 SEETRVWHRRDSKWQNVHFHCSGAPAAPLQ 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAMK2B	XP_011513849.1	STKc_CaMKII	12..303	CDD:270988	282/290 (97%)
		CaMKII_AD	577..704	CDD:285524	117/126 (93%)
camk2b1	XP_021331894.1	STKc_CaMKII	11..302	CDD:270988	282/290 (97%)
		CaMKII_AD	561..688	CDD:285524	117/126 (93%)