Protein Alignment CAMK2B and CASK

DIOPT Version :10

• Sequence 1: XP_011513849.1
• Gene: CAMK2B / 816
• HGNCID: 1461
• Length: 709
• Species: Homo sapiens
• Sequence 2: NP_001262811.1
• Gene: CASK / 42567
• FlyBaseID: FBgn0013759
• Length: 929
• Species: Drosophila melanogaster
• Alignment Length: 539
• Identity: 174/539 - (32%)
• Similarity: 252/539 - (46%)
• Gaps: 106/539 - (19%)

Human    10 FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKK------LSARDHQKLEREARICRLL 68
            |.|.|:|.|.||||.||:||||:...:..::|.||::..|      ||..|   |:|||.||.:|
  Fly     8 FDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTAD---LKREATICHML 69

Human    69 KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVARE----YYSEADASHCIQQILEAVLHCHQ 129
            ||.:||.|.::.|.||..|:||:.:.|.:|..::|.|.    .||||.|.|.::|||||:.:||:
  Fly    70 KHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHE 134

Human   130 MGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQA--WFGFAGTPGYLSPEVLRKEAYG 192
            ..::|||::|...|||:....|.|||..||.||::.|.::.  ..|..|.|.|::|||:.:..||
  Fly   135 NDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYG 199

Human   193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINP 257
            |..|:|..||:|::||.|..||..... :|.|.:..|...|.:|||.:::..||:|:.:||..||
  Fly   200 KGCDVWGAGVMLHVLLSGRLPFLGSGV-RLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANP 263

Human   258 AKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTA 322
            ..|::..|.|.|||:..|..: ...|..:|||.||::|||||||||:
  Fly   264 HHRLSITEVLDHPWIRDRDKL-QRTHLADTVEELKRYNARRKLKGAV------------------ 309

Human   323 PATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVI--- 384
                ...|.||.|      ..|....||  .|.|.:|...|.        ..|.:|....::
  Fly   310 ----QAIAGGTNM------DPLYATDAD--MPITGATDEWAD--------EEAGIEAVQRILDCL 354

Human   385 ---------HNPVDGIKES------------SDSANTTIEDEDAKAP------RVPDILSSVRRG 422
                     |...|.:::.            .|....|:...:.:||      |..|:|..:...
  Fly   355 DDIYSLQDAHVDADVLRDMLRDNRLHQFLQLFDRIAATVVTSNGRAPAAEAVGRCRDVLEQLSST 419

Human   423 SGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNS---VRRGSGTPEAEGPLSAGPPPCLSPALLG 484
            ||.....|..   :......|.| :|.:..:|:|   |.|.....||   |...||| :.|.|.|
  Fly   420 SGGNSLGGKY---AKEELMRLLA-APHMQALLHSHDVVARDVYGEEA---LRVTPPP-MVPYLNG 476

Human   485 PLSSPSPRISDILNSVRRG 503
                      |.|::|..|
  Fly   477 ----------DELDNVEGG 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAMK2B	XP_011513849.1	STKc_CaMKII	12..303	CDD:270988	126/302 (42%)
		CaMKII_AD	577..704	CDD:285524
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	127/304 (42%)
		L27	347..396	CDD:460717	4/48 (8%)
		L27	406..462	CDD:460717	13/59 (22%)
		PDZ_CASK-like	494..574	CDD:467267
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:395500