DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLPB and HSP78

DIOPT Version :9

Sequence 1:	NP_110440.1	Gene:	CLPB / 81570	HGNCID:	30664	Length:	707	Species:	Homo sapiens
Sequence 2:	NP_010544.3	Gene:	HSP78 / 851845	SGDID:	S000002666	Length:	811	Species:	Saccharomyces cerevisiae

Alignment Length:	738	Identity:	206/738 - (27%)
Similarity:	319/738 - (43%)	Gaps:	143/738 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    19 RLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSP-----ALFSGRGAATGGRQGGRF 78
            |...:|.|.|..|. |:......|.:    |:..|..|.:..     ||..| ....|.:..|.|
Yeast   134 RTKNNPCLIGRAGV-GKTALIDGLAQ----RIVAGEVPDSLKDKDLVALDLG-SLIAGAKYRGEF 192

Human    79 DTKCLAAATWGRLPGPEETLPGQDSWNG--------VPSRAGLGMC------------ALAAALV 123
            :.:.            ::.|...|..||        |....|||..            .||..|
Yeast   193 EERL------------KKVLEEIDKANGKVIVFIDEVHMLLGLGKTDGSMDASNILKPKLARGL- 244

Human   124 VHCYSKSPSN------KDAA--------LLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVA 174
             .|.|.:..:      ||.|        ||.....::...:.|.|.|..:|:...|:..|||:.|
Yeast   245 -RCISATTLDEFKIIEKDPALSRRFQPILLNEPSVSDTISILRGLKERYEVHHGVRITDTALVSA 308

Human   175 AINRNNSVVQVLLAAGADPNLGDDFSSVYK---TAKEQGIHSLEDGGQDGASRHITNQWTS---- 232
            |:..|..:....|...| .:|.|:..:|.:   .:|...|..|     |.|...|..:..|
Yeast   309 AVLSNRYITDRFLPDKA-IDLVDEACAVLRLQHESKPDEIQKL-----DRAIMKIQIELESLKKE 367

Human   233 ----ALEFRRWLGLPAGVLITREDDFNNRLN-----NRA---SFKGCTA--------LHYAVLAD 277
                ::|.|..|...    :..::|..|||.     .||   |.|...|        |.......
Yeast   368 TDPVSVERREALEKD----LEMKNDELNRLTKIWDAERAEIESIKNAKANLEQARIELEKCQREG 428

Human   278 DYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLR---TSE--AKYQEK------QRKREA 331
            ||....||.......|::..   ...:.:::|:.:.||.   ||:  :|...|      :...:.
Yeast   429 DYTKASELRYSRIPDLEKKV---ALSEKSKDGDKVNLLHDSVTSDDISKVVAKMTGIPTETVMKG 490

Human   332 EERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLV-FLFLGSSGIGKTELAKQTA 395
            ::.|...:|..|||.::||:.|||.:..|:|.:..|...|:.|:. |:|||.:|.|||||.|..|
Yeast   491 DKDRLLYMENSLKERVVGQDEAIAAISDAVRLQRAGLTSEKRPIASFMFLGPTGTGKTELTKALA 555

Human   396 KYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAH 460
            :::..| :...||.|||||||:|.|::.||:|||||..|.|||||:.:::.|.|||||||.:|||
Yeast   556 EFLFDD-ESNVIRFDMSEFQEKHTVSRLIGAPPGYVLSESGGQLTEAVRRKPYAVVLFDEFEKAH 619

Human   461 PDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENL 525
            |||..::||:.|||:|||..|..:|.::.|.:||||:..|.:                      |
Yeast   620 PDVSKLLLQVLDEGKLTDSLGHHVDFRNTIIVMTSNIGQDIL----------------------L 662

Human   526 GDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQLVNKEL-NFWAK 589
            .|.::.|...|....|..||..:.:::  ..||:.||::|:.|.......|..:|:..: ....:
Yeast   663 NDTKLGDDGKIDTATKNKVIEAMKRSY--PPEFINRIDDILVFNRLSKKVLRSIVDIRIAEIQDR 725

Human   590 RAKQRHNITLLWDREVADVLVD-GYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITV 653
            .|::|..|.|  ..|..|.|.| ||:..||||.:...:.|:::|.:|....:..:..|.|:|:.|
Yeast   726 LAEKRMKIDL--TDEAKDWLTDKGYDQLYGARPLNRLIHRQILNSMATFLLKGQIRNGETVRVVV 788

Human   654 EDSDKQLL---KSPELPSPQAEK 673
            :|:...:|   :..|:...:|||
Yeast   789 KDTKLVVLPNHEEGEVVEEEAEK 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLPB	NP_110440.1	MCR_beta_N	<78..>211	CDD:332183	36/169 (21%)
		ANK 1	133..162		9/42 (21%)
		ANK	137..315	CDD:238125	45/212 (21%)
		ANK repeat	137..164	CDD:293786	7/34 (21%)
		ANK repeat	166..197	CDD:293786	9/30 (30%)
		ANK 2	166..195		8/28 (29%)
		ANK 3	265..295		8/37 (22%)
		ANK repeat	265..290	CDD:293786	7/32 (22%)
		ANK 4	298..327		7/39 (18%)
		ClpA	<339..655	CDD:223616	117/318 (37%)
HSP78	NP_010544.3	chaperone_ClpB	88..794	CDD:274529	201/719 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I1104
eggNOG	1	0.900	-	-		E1_COG0542
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4393
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001537
OrthoInspector	1	1.000	-	-		otm52810
orthoMCL	1	0.900	-	-		OOG6_100223
Panther	1	1.100	-	-	O	PTHR11638
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R570
SonicParanoid	1	1.000	-	-		X1277
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.750