DRSC/TRiP Functional Genomics Resources

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Protein Alignment CLPB and Torsin

DIOPT Version :10

Sequence 1:NP_110440.1 Gene:CLPB / 81570 HGNCID:30664 Length:707 Species:Homo sapiens
Sequence 2:NP_572178.1 Gene:Torsin / 31399 FlyBaseID:FBgn0025615 Length:340 Species:Drosophila melanogaster


Alignment Length:330 Identity:86/330 - (26%)
Similarity:133/330 - (40%) Gaps:61/330 - (18%)


- Green bases have known domain annotations that are detailed below.


Human   292 PLQRNEMGHTPLDYAREGEVMKLLRTSEAKYQEKQRKREAE--ERRRFP-----LEQRLKEHIIG 349
            |||..:    ||.....|.|     ...|.::|....|.||  :.|..|     ||:.|:..:||
  Fly    21 PLQSVD----PLTIGAVGAV-----ALGAYFKEHTYCRFAECCDDRNIPARIDELERSLERTLIG 76

Human   350 QESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYMH-KDAKKGFIR--LDM 411
            |......:..|::...........|||..|.|..|.||..:|:|.|..|: |.::..::.  |..
  Fly    77 QHIVRQHIVPALKAHIASGNKSRKPLVISFHGQPGTGKNFVAEQIADAMYLKGSRSNYVTKYLGQ 141

Human   412 SEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRL 476
            ::|.:..||:.:        ..:....:...|:.||.::.:||||||....|...:..|.|....
  Fly   142 ADFPKESEVSNY--------RVKINNAVRDTLRSCPRSLFIFDEVDKMPSGVFDQLTSLVDYNAF 198

Human   477 TDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFK 541
            .||...|    .||||..||.|...||.|...:      |...|:.|   |.::||         
  Fly   199 VDGTDNT----KAIFIFLSNTAGSHIASHLGSV------MKNGRLRE---DTRLSD--------- 241

Human   542 ENVIRPIL-KAHFRRDEFLGR--------INEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNI 597
               ..|:| ||.:..|..:.:        |:..:.|||...:.:|:.:..||..|.:..||.:|.
  Fly   242 ---FEPLLRKAAYNMDGGMKKTTMIESHVIDHFIPFLPMEKAHVIKCLEAELLRWRRDPKQANNQ 303

Human   598 TLLWD 602
            .::.|
  Fly   304 KIIED 308

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CLPBNP_110440.1 Autoinhibitory. /evidence=ECO:0000269|PubMed:32573439 92..126
ANKYR <132..321 CDD:440430 7/28 (25%)
ANK 1 133..162
ANK repeat 137..164 CDD:293786
ANK repeat 166..197 CDD:293786
ANK 2 166..195
ANK 3 265..295 2/2 (100%)
ANK repeat 265..290 CDD:293786
ANK 4 298..327 6/28 (21%)
ClpA <339..655 CDD:440308 72/276 (26%)
Regulatory, slows ATPase and disaggregase activities. /evidence=ECO:0000269|PubMed:36170828 507..535 6/27 (22%)
TorsinNP_572178.1 P-loop containing Nucleoside Triphosphate Hydrolases 55..175 CDD:476819 29/127 (23%)
Blue background indicates that the domain is not in the aligned region.

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