DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLPB and SPBC4F6.17c

DIOPT Version :9

Sequence 1:	NP_110440.1	Gene:	CLPB / 81570	HGNCID:	30664	Length:	707	Species:	Homo sapiens
Sequence 2:	NP_596117.1	Gene:	SPBC4F6.17c / 2540898	PomBaseID:	SPBC4F6.17c	Length:	803	Species:	Schizosaccharomyces pombe

Alignment Length:	826	Identity:	198/826 - (23%)
Similarity:	336/826 - (40%)	Gaps:	212/826 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    21 LRSPTLRGHGGA---SGRNVTTGSLGEPQWL-RVATGGRPGTSPALFSGRGAATGGRQ------- 74
            :|..:||.:.|:   |.|.::|..:.|.:.| ......||..:..|.:.|....|.:|
pombe    10 IRIQSLRRYQGSLKTSLRALSTRPIFEKRLLAETPFSIRPSNASVLIAKRSPKFGWKQVRFYAAN 74

Human    75 -----------GGR--------FDTKCLAAATWGRLP---GPEETLP------GQDSWN--GVPS 109
                       |||        :.|...|.|..|:|.   |.||.:.      .:.:.|  .:..
pombe    75 PNGGNFRMDLGGGRKQGAALEEYGTDLTALAKQGKLDPVIGREEEIQRTIQILSRRTKNNPALVG 139

Human   110 RAGLGMCALAAALVVHCY-SKSP-SNKD--------AALLEAA--RANNMQEVSRLLS--EGAD- 159
            .||:|..|:...|..... .:.| |.||        .||:..|  |.:..:.:..:||  |||:
pombe   140 PAGVGKTAIMEGLASRIIRGEVPESMKDKRVIVLDLGALISGAKFRGDFEERLKSVLSDLEGAEG 204

Human   160 -----VNAKHRLGWTALMVAAINRNNSVVQVLLAAGA---------------------------- 191
                 |:..|.|........:|:.:| :::..||.|.
pombe   205 KVILFVDEMHLLLGFGKAEGSIDASN-LLKPALARGKLHCCGATTLEEYRKYIEKDAALARRFQA 268

Human   192 ----DPNLGDDFSSVYKTAKEQ-----GIHSLEDGGQDGA---SRHITNQW------------TS 232
                :|::.|.. |:.:..||:     |:...:|.....|   :|:||:::            .|
pombe   269 VMVNEPSVADTI-SILRGLKERYEVHHGVRITDDALVTAATYSARYITDRFLPDKAIDLVDEACS 332

Human   233 AL---------EFRRWLGLPAGVL-----------------ITREDDFNNRLNNRASFKGCTALH 271
            :|         |.||   |...::                 :.|.:...::|.:....:...:..
pombe   333 SLRLQQESKPDELRR---LDRQIMTIQIELESLRKETDTTSVERREKLESKLTDLKEEQDKLSAA 394

Human   272 Y---AVLADDYRTVKELLDGGANPLQR-----NEMGHTPLDYAREGEVMKLLRTSEAKYQEKQ-- 326
            :   ..|.|..:..|..|:.....|:|     |....:.|.||...|:.:.:...|...:||:
pombe   395 WEEERKLLDSIKKAKTELEQARIELERTQREGNYARASELQYAIIPELERSVPKEEKTLEEKKPS 459

Human   327 ------------------------RKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENG 367
                                    .....|..:...:||.:.:.||||:.|:..:..|:|....|
pombe   460 MVHDSVTSDDIAVVVSRATGIPTTNLMRGERDKLLNMEQTIGKKIIGQDEALKAIADAVRLSRAG 524

Human   368 WYDEEHPLV-FLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYV 431
            ..:...||. |||||.:|:|||.|.|..|:::. |..|..||.|||||||:|.:|:.|||||||:
pombe   525 LQNTNRPLASFLFLGPTGVGKTALTKALAEFLF-DTDKAMIRFDMSEFQEKHTIARLIGSPPGYI 588

Human   432 GHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSN 496
            |:||.|:||:.:::.|.||:||||::|||.|:..::||:.|||.|||.:|:.:|.:..:.:||||
pombe   589 GYEESGELTEAVRRKPYAVLLFDELEKAHHDITNLLLQVLDEGFLTDSQGRKVDFRSTLIVMTSN 653

Human   497 VASDEIAQHALQLRQEALEMSRNRIAENLGDVQISD-KITISKNFKENVIRPILKAHFRRDEFLG 560
            :.|                           |:.::| ..|::...::.|:..:.|  :...|||.
pombe   654 LGS---------------------------DILVADPSTTVTPKSRDAVMDVVQK--YYPPEFLN 689

Human   561 RINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHE 625
            ||::.:.|.......|..:||..|:...:|...|..|..:.:.....:...||:..||||.:...
pombe   690 RIDDQIVFNKLSEKNLEDIVNVRLDEVQQRLNDRRIILTVTEAARKWLAEKGYSPAYGARPLNRL 754

Human   626 VERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPELPSPQA 671
            :::|::|.:|....|..:.....:.|.|.|.:.: .|:.:| .||:
pombe   755 IQKRILNTMAMKIIQGEIKSDENVVIDVLDGELE-FKANKL-EPQS 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLPB	NP_110440.1	MCR_beta_N	<78..>211	CDD:332183	40/200 (20%)
		ANK 1	133..162		12/46 (26%)
		ANK	137..315	CDD:238125	47/273 (17%)
		ANK repeat	137..164	CDD:293786	10/36 (28%)
		ANK repeat	166..197	CDD:293786	7/62 (11%)
		ANK 2	166..195		7/60 (12%)
		ANK 3	265..295		5/32 (16%)
		ANK repeat	265..290	CDD:293786	4/27 (15%)
		ANK 4	298..327		7/54 (13%)
		ClpA	<339..655	CDD:223616	106/317 (33%)
SPBC4F6.17c	NP_596117.1	AAA	114..267	CDD:99707	30/153 (20%)
		AAA	131..274	CDD:214640	27/143 (19%)
		AAA_2	532..693	CDD:285025	75/190 (39%)
		AAA	536..659	CDD:214640	64/150 (43%)
		ClpB_D2-small	700..789	CDD:198154	20/89 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	149	1.000	Domainoid score	I1272
eggNOG	1	0.900	-	-		E1_COG0542
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001537
OrthoInspector	1	1.000	-	-		otm53486
orthoMCL	1	0.900	-	-		OOG6_100223
Panther	1	1.100	-	-	O	PTHR11638
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R570
SonicParanoid	1	1.000	-	-		X1277
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.800