DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLPB and clpb

DIOPT Version :9

Sequence 1:	NP_110440.1	Gene:	CLPB / 81570	HGNCID:	30664	Length:	707	Species:	Homo sapiens
Sequence 2:	XP_031753289.1	Gene:	clpb / 100145643	XenbaseID:	XB-GENE-994913	Length:	677	Species:	Xenopus tropicalis

Alignment Length:	716	Identity:	459/716 - (64%)
Similarity:	529/716 - (73%)	Gaps:	79/716 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    20 LLRSPTLRGHGGASGRNVT----TGSLGEPQWLRVATGGRPGTSPALFSGRGAATG--------- 71
            :|||       |.||..||    .||......|..|.|....|..|    :||||.
Frog     1 MLRS-------GLSGLGVTRLLSCGSEPNSVTLTAALGLVQRTETA----QGAATAQYRHTDTRW 54

Human    72 -GRQGGRF-------------DTKC-------LAAATWGRLPGPEETLPGQDSWNGVPSRAGLGM 115
             ....|||             ||:.       :...|...|...||....:.:.:|..|....|:
Frog    55 RWETAGRFYRTTGHSLQYRHTDTRWRWETASRILNNTGHSLQYREEPSGRRQNDSGKKSSDRSGV 119

Human   116 CALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNN 180
            .||.|||:.:|||:...:|...||.|||.....||.|||:|..|.|::||||||.|||||:.||.
Frog   120 QALTAALLAYCYSRGNKSKGEELLVAARDGIAPEVERLLAEKVDPNSRHRLGWTPLMVAAMGRNQ 184

Human   181 SVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAG 245
            |:|:.||.|||||||||:|.:|::|:||:|:||||
Frog   185 SIVKSLLRAGADPNLGDEFCNVHETSKEKGLHSLE------------------------------ 219

Human   246 VLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGE 310
            ||:||||:|::||||||||:||||||||||||||.||:|||:|||||.|:|:|||||:|||||||
Frog   220 VLVTREDEFSDRLNNRASFRGCTALHYAVLADDYGTVRELLEGGANPQQKNDMGHTPIDYAREGE 284

Human   311 VMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPL 375
            :.:|||..|:::||:||||:.|||||||||:||||||:|||||||||.|||||||||||||||||
Frog   285 LKQLLRGWESRFQEEQRKRDMEERRRFPLERRLKEHIVGQESAIATVAAAIRRKENGWYDEEHPL 349

Human   376 VFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLT 440
            ||||||||||||||||||||:|||||.||||||||||||||:|||||||||||||||||||||||
Frog   350 VFLFLGSSGIGKTELAKQTARYMHKDIKKGFIRLDMSEFQEKHEVAKFIGSPPGYVGHEEGGQLT 414

Human   441 KKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQH 505
            |||||||:||||||||||||||||||||||||||||||||||||:|||||||||.|..||||||:
Frog   415 KKLKQCPDAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTIECKDAIFIMTCNAGSDEIAQY 479

Human   506 ALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLP 570
            .|||||||.|:::.|:|:||.|:|.|:||||||.|||||||||||||||||||||||||||||||
Frog   480 GLQLRQEAHEINKKRLAQNLDDIQTSEKITISKQFKENVIRPILKAHFRRDEFLGRINEIVYFLP 544

Human   571 FCHSELIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLA 635
            ||.|||.|||.||||.|||:|||||:|||:||.||.|||.|||||||||||||||||||||||||
Frog   545 FCRSELSQLVRKELNSWAKKAKQRHSITLMWDPEVIDVLADGYNVHYGARSIKHEVERRVVNQLA 609

Human   636 AAYEQDLLPGGCTLRITVEDSDKQLLKSPELPSPQAEKRLPKLRLEIIDKDSKTRRLDIRAPLHP 700
            |||||||||.||||||||||||::|:|.    ....|.:..:||||::::.|:.|:||||.||.|
Frog   610 AAYEQDLLPRGCTLRITVEDSDRRLMKE----GKGEEGKGARLRLELVEQGSEGRKLDIREPLTP 670

Human   701 E 701
            |
Frog   671 E 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLPB	NP_110440.1	MCR_beta_N	<78..>211	CDD:332183	63/152 (41%)
		ANK 1	133..162		13/28 (46%)
		ANK	137..315	CDD:238125	102/177 (58%)
		ANK repeat	137..164	CDD:293786	13/26 (50%)
		ANK repeat	166..197	CDD:293786	22/30 (73%)
		ANK 2	166..195		20/28 (71%)
		ANK 3	265..295		24/29 (83%)
		ANK repeat	265..290	CDD:293786	20/24 (83%)
		ANK 4	298..327		18/28 (64%)
		ClpA	<339..655	CDD:223616	279/315 (89%)
clpb	XP_031753289.1	ANKYR	84..>280	CDD:223738	112/225 (50%)
		Ank_2	142..270	CDD:403870	89/157 (57%)
		ANK repeat	142..168	CDD:293786	13/25 (52%)
		ANK repeat	170..201	CDD:293786	22/30 (73%)
		ANK repeat	239..270	CDD:293786	25/30 (83%)
		ClpA	<307..629	CDD:223616	285/321 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	342	1.000	Domainoid score	I7723
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H32067
Inparanoid	1	1.050	853	1.000	Inparanoid score	I4022
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D108553at7742
OrthoFinder	1	1.000	-	-		FOG0001537
OrthoInspector	1	1.000	-	-		oto148683
Panther	1	1.100	-	-	LDO	PTHR11638
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R570
SonicParanoid	1	1.000	-	-		X1277
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.190