DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC38A1 and CG43693

DIOPT Version :9

Sequence 1:	NP_001265319.1	Gene:	SLC38A1 / 81539	HGNCID:	13447	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_001261694.1	Gene:	CG43693 / 39231	FlyBaseID:	FBgn0263776	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	111/508 - (21%)
Similarity:	209/508 - (41%)	Gaps:	92/508 - (18%)

- Green bases have known domain annotations that are detailed below.

Human     6 SGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFI-SD------RESRRSLTNSHLEKKKC 63
            ||:..|.|....:|.......::......:.||  |||| ||      :::..|.....:.:||.
  Fly    78 SGVMTTSLDQQKIPTVTAGYGENEKPKGGKGGQ--SKFIRSDMADVPVQQAAGSTLPLVISRKKG 140

Human    64 DEYIPG-------------TTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLS 115
            |:...|             |:.|...| :|....:|||||.:..|.::.|:...||...:|..|.
  Fly   141 DDSEDGNYNPFEHRKVEHPTSDLETFV-HLLKGSLGSGILAMPMAFSHAGLWFGLVATFAVGTLC 204

Human   116 IYSINLLLICS------KETGCMVYEKLGEQVF-------GTTGKFVIFGATSLQNT-------G 160
            .|.:::|:.|:      ::...|.:..:.||.|       ....:|:.|    :.||       |
  Fly   205 TYCVHILVKCAHILCRRRKIPMMGFADVAEQAFLDGPPALNRWSRFIRF----MVNTFLVIDLLG 265

Human   161 AMLSYLFIVKNELPSAIKFLMGKEETFSAWYVDGRVLVVIVTFGIILPLCLLKNLGYLGYTSGFS 225
            ....||..|...:...::..|..|.:...|       ::|||..:|. :||::||.:|   :.||
  Fly   266 CCCIYLVFVATNVEQVVRVYMETELSIRVW-------IMIVTAPLIF-MCLVRNLKFL---TPFS 319

Human   226 L--SCMVFFLIVV--IYKKFQIPCIVPELNSTISANSTNADTCTPKYVTFNSKTVYALPTIAFAF 286
            :  :.::|..||:  ||....||..| |....:|..         ::..|....::||..|..
  Fly   320 MIANILMFVGIVITFIYMFSDIPAPV-ERPGIVSVT---------EWPLFFGTVIFALEGIGV-- 372

Human   287 VCHPSVLPIYSELKDRSQ-KKMQMVSNISFFAMFVMYFLTAIFGYLTFYDNVQSDLLHKYQSKDD 350
                 |:.:.:::|:.|. .....|.|.....:..:|.|...||:|.:....|:.:......:|.
  Fly   373 -----VMSLENDMKNPSHFIGCPSVLNFGMGLVIALYTLVGFFGFLKYGPETQASITLNLPLEDK 432

Human   351 ILILTVRLAVIVAVILTVPVLFFTVRSSLFE----LAKKTKFNLCRHTVVTCILLVVINLLVIFI 411
             |..:|:|.:.:|:..|..:.|:...:.|::    ..:..|.|:..:. :...|:::...:.:.:
  Fly   433 -LAQSVKLMIAIAIFFTFTLQFYVPVTILWKGLEHKIRPEKQNISEYG-LRVFLVLLCGGIAVAL 495

Human   412 PSMKDIFGVVGVTSANMLIFILPSSLYLKITDQDGDKG--TQRIW----LFLF 458
            |::.....::|....:.|..|:|:::.|.:..:|...|  ..|:|    |.||
  Fly   496 PNLGPFISLIGAVCLSTLGMIVPATIELAVYHEDPGYGRFNWRLWKNSGLILF 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC38A1	NP_001265319.1	SLC5-6-like_sbd	69..480	CDD:382020	94/438 (21%)
CG43693	NP_001261694.1	SdaC	153..561	CDD:223884	93/431 (22%)
CG43693	NP_001261694.1	SLC5-6-like_sbd	158..562	CDD:294310	93/426 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820