DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC38A1 and CG30394

DIOPT Version :9

Sequence 1:	NP_001265319.1	Gene:	SLC38A1 / 81539	HGNCID:	13447	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_611578.1	Gene:	CG30394 / 37437	FlyBaseID:	FBgn0050394	Length:	831	Species:	Drosophila melanogaster

Alignment Length:	409	Identity:	106/409 - (25%)
Similarity:	183/409 - (44%)	Gaps:	66/409 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    77 VFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQV 141
            |..|:|:|:|.|||.:.|.....||||.:|||.....::....:.|:..|..|....:|.||...
  Fly     8 VMTLANSIIGVGILAMPFCFQKCGILLSIVLLVLSNGITRVCCHYLIKTSLLTRRRSFEMLGLHA 72

Human   142 FGTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEETFSAWYVDGRVLV-VIVTFGI 205
            |||:||.::.........|..::|..:|.:..|..|..:...:   .|.::..|.|| |:||...
  Fly    73 FGTSGKLLVELCIIGYLIGTCITYFVVVGDLGPQIIAKIFALD---VADHLHLRSLVMVVVTVVC 134

Human   206 ILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFQIPCIVPELNSTISANSTNADTCTPKYVT 270
            |:||.:|:|:..|......|:.    |.:.:|.|      ||.|....|:||.
  Fly   135 IVPLGMLRNVDSLSAVCTASIG----FYVCLILK------IVLEAQPHITAND------------ 177

Human   271 FNSKTVY--------ALPTIAFAFVCHPSVLPIYSELKDRSQKKMQ-MVSNISFFAMFVMYFLTA 326
            :..|.:|        .||..:.|..|...:..::..:.::|..|:. :|.|.::...|| |....
  Fly   178 WTEKVLYWEPAGVLQCLPIFSMALSCQMQLFEVFESINNQSLDKLNGIVRNATWICTFV-YISVG 241

Human   327 IFGYL-----TFYDNVQSDLLHKYQSKDDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKT 386
            .|||:     ||..|:..:|...:.|  ||    :::..::::..:.|::.|..|:||:.|..:.
  Fly   242 FFGYVAFCTHTFSGNILVNLSTSFGS--DI----IKIGFVLSIAFSFPLVIFPCRASLYSLLYRK 300

Human   387 KFNLCRHT------------VVTCILLVVINLLV-IFIPSMKDIFGVVGVTSANMLIFILPSSLY 438
                 .||            .:| |.:||.:|.| :.|||::.|.|:||.|....:..:.|:|.:
  Fly   301 -----GHTESSSYIPEQRFRFIT-IFIVVFSLCVALVIPSVELIIGLVGSTIGVAICIMFPASSF 359

Human   439 LKITDQDGDKGTQRIWLFL 457
            .||..::..:.|...::|:
  Fly   360 RKIIKKESMERTLAQFVFV 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC38A1	NP_001265319.1	SLC5-6-like_sbd	69..480	CDD:382020	106/409 (26%)
CG30394	NP_611578.1	SdaC	8..392	CDD:223884	106/409 (26%)
		SLC5-6-like_sbd	8..390	CDD:294310	106/409 (26%)
		DUF4775	<394..652	CDD:292620
		YukC	<561..660	CDD:295067
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840