Protein Alignment HM13 and SppL

DIOPT Version :10

• Sequence 1: NP_848696.1
• Gene: HM13 / 81502
• HGNCID: 16435
• Length: 426
• Species: Homo sapiens
• Sequence 2: NP_001163740.1
• Gene: SppL / 43128
• FlyBaseID: FBgn0039381
• Length: 422
• Species: Drosophila melanogaster
• Alignment Length: 418
• Identity: 115/418 - (27%)
• Similarity: 172/418 - (41%)
• Gaps: 115/418 - (27%)

Human    11 GSAEAGGP-------TNSTTRPPSTPEGIALAYGSLLLMALLPIFFGALRSV--------RCARG 60
            |:|.|||.       |.|:....|..        |..|:::|.|.:|:.||:        |..:.
  Fly    23 GAAAAGGGEYRELHWTVSSVMDSSRV--------STCLISMLLIVYGSFRSLNIEQEAREREQKK 79

Human    61 KNAS--------------------DMPETITSRDAARFPIIASCTLLGLYLFFKIFSQEYINLLL 105
            :|.|                    |...|:.:..|...|:.||.:||.::.||     :.:.||.
  Fly    80 RNESMTNLLTGEPVEKEPNLYFTADKFATLDTMHALCLPLGASISLLIMFFFF-----DSMQLLF 139

Human   106 SMYFFVLGILALSHTISPFMNKFFPASFPNRQYQLLFTQGSGENKEEIINYEFDTKDLVCLGLS- 169
            ::...::..:||:..:.|............:::...|..            .|...:|....||
  Fly   140 AVCTAIIATVALAFLLLPMCQYIIRPCTDGKRFSFGFCG------------RFTAAELFSFTLSV 192

Human   170 SIVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDVFWV------FGTNV 228
            |||.:| :|..||:..:..|:...:..:..:.|.::....:||.||.|||||||      |.|||
  Fly   193 SIVCIW-VLTGHWLLMDAMGMGLCVAFIAFVRLPSLKVSTLLLTGLLIYDVFWVFLSSYIFSTNV 256

Human   229 MVTVA------------------------KSFEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIP 269
            ||.||                        .....|.||||| .|...|    :|:||||||||:|
  Fly   257 MVKVATRPADNPVGIVARKLHLGGIVRDTPKLNLPGKLVFP-SLHNTG----HFSMLGLGDVVMP 316

Human   270 GIFIALLLRFDISLKK-----------------NTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQP 317
            |:.:..:||:| :.||                 :..|||:.|...|..||........:||.|||
  Fly   317 GLLLCFVLRYD-AYKKAQGVTSDPTLSPPRGVGSRLTYFHCSLLGYFLGLLTATVSSEVFKAAQP 380

Human   318 ALLYLVPACIGFPVLVALAKGEVTEMFS 345
            |||||||..:...:|:|..||::..|:|
  Fly   381 ALLYLVPFTLLPLLLMAYLKGDLRRMWS 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HM13	NP_848696.1	Peptidase_A22B	63..350	CDD:282158	98/351 (28%)
SppL	NP_001163740.1	Peptidase_A22B	102..413	CDD:282158	97/331 (29%)