DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAMK2A and CMK1

DIOPT Version :9

Sequence 1:	NP_001350918.1	Gene:	CAMK2A / 815	HGNCID:	1460	Length:	489	Species:	Homo sapiens
Sequence 2:	NP_116669.1	Gene:	CMK1 / 850568	SGDID:	S000001910	Length:	446	Species:	Saccharomyces cerevisiae

Alignment Length:	412	Identity:	133/412 - (32%)
Similarity:	208/412 - (50%)	Gaps:	33/412 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQ--KLEREARICRLLKHPNIV 73
            ::|...:.||.|.|.|||:......|::.|.||:..|.|.....|  .|..|..|.:.|.|||||
Yeast    35 KKYVFGKTLGAGTFGVVRQAKNTETGEDVAVKILIKKALKGNKVQLEALYDELDILQRLHHPNIV 99

Human    74 RLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKP 138
            ...|....:...|:|..|..|||||:.|:.:..::|.||...:.:||.||.:.|...:|||||||
Yeast   100 AFKDWFESKDKFYIITQLAKGGELFDRILKKGKFTEEDAVRILVEILSAVKYMHSQNIVHRDLKP 164

Human   139 ENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVIL 203
            ||||...|...:.:.:||||:|..::.:::..:..||:.||::||||.:|.:|||.|:|:.|||.
Yeast   165 ENLLYIDKSDESPLVVADFGIAKRLKSDEELLYKPAGSLGYVAPEVLTQDGHGKPCDIWSIGVIT 229

Human   204 YILLVGYPPFWDEDQHRLYQQIKAGAY--DFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEAL 266
            |.||.||..|..|.......:...|.|  .|..|.||:|:.:||..|.|.|.::||||.||||.|
Yeast   230 YTLLCGYSAFRAERVQDFLDECTTGEYPVKFHRPYWDSVSNKAKQFILKALNLDPSKRPTAAELL 294

Human   267 KHPWI--SHRSTVASCMHRQETVDCLKKF---------NAR-RKLKGAILTTMLATRNFSGGKSG 319
            :.|||  :...|.......:|.:|..:||         |.: :||:...|....:..:|    ..
Yeast   295 EDPWIICTELKTHNLLPGLKEGLDARQKFRNSVERVRLNMKIQKLRDLYLEQTESDSDF----DE 355

Human   320 GNKKSDGVKKRKSSSSVQLMESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAI--SNGDFESYTK 382
            |::.:..|...|::.:.||.:...      |:|.:|::.:...|...||:..:  ....|.:..:
Yeast   356 GSQANGSVPPLKATDTSQLSKKLS------EEEQSKLKSELTSKAFAQLVNTVLAEKEKFLNINR 414

Human   383 MCDPGMTAFEPEALGNLVEGLD 404
            :|     :.:.:..|:.::.||
Yeast   415 VC-----SSDSDLPGSDIKSLD 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAMK2A	NP_001350918.1	STKc_CaMKII	11..302	CDD:270988	115/306 (38%)
CAMK2A	NP_001350918.1	CaMKII_AD	357..484	CDD:285524	8/50 (16%)
CMK1	NP_116669.1	STKc_CAMK	36..298	CDD:270687	104/261 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910