DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAMK2A and lok

DIOPT Version :9

Sequence 1:	NP_001350918.1	Gene:	CAMK2A / 815	HGNCID:	1460	Length:	489	Species:	Homo sapiens
Sequence 2:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster

Alignment Length:	269	Identity:	94/269 - (34%)
Similarity:	151/269 - (56%)	Gaps:	11/269 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLS-AR------DHQKLEREARICRLLKHP 70
            |.:..:||.||:.:||........|::|.||:....|| ||      |..::..||:|.:.|.||
  Fly   174 YYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHP 238

Human    71 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRD 135
            .:||:||.:.:....|::.:.:.||:|...|::.:..||..:.....|:..||.:.|..|:.|||
  Fly   239 CVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRD 303

Human   136 LKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDLW 197
            |||:|:||.:..:...:|::||||:..|: :........|||.|::||||   .::.|.|.||:|
  Fly   304 LKPDNVLLETNDEETLLKVSDFGLSKFVQ-KDSVMRTLCGTPLYVAPEVLITGGREAYTKKVDIW 367

Human   198 ACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITA 262
            :.||:|:..|.|..||.||......||||.|.:.:..|.|.:|:..||.|||:||.::|.:|.:.
  Fly   368 SLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSI 432

Human   263 AEALKHPWI 271
            .:.|:..|:
  Fly   433 DDVLQSSWL 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAMK2A	NP_001350918.1	STKc_CaMKII	11..302	CDD:270988	94/269 (35%)
CAMK2A	NP_001350918.1	CaMKII_AD	357..484	CDD:285524
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	93/267 (35%)
		S_TKc	174..441	CDD:214567	93/267 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910