Protein Alignment CAMK2A and PhKgamma

DIOPT Version :10

• Sequence 1: NP_057065.2
• Gene: CAMK2A / 815
• HGNCID: 1460
• Length: 489
• Species: Homo sapiens
• Sequence 2: NP_511129.3
• Gene: PhKgamma / 32120
• FlyBaseID: FBgn0011754
• Length: 560
• Species: Drosophila melanogaster
• Alignment Length: 376
• Identity: 128/376 - (34%)
• Similarity: 190/376 - (50%)
• Gaps: 42/376 - (11%)

Human     9 FTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIIN----TKKLSARDHQKLE---REARICR- 65
            |..:|:..|.||:|..|.||||::...|:|:|||||:    |:......:..||   :|..|.|
  Fly    19 FYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILRQ 83

Human    66 LLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 130
            ::.||.|:.|.|....:...:|:|:|...||||:.:.:....||......::||.|.|.:.|...
  Fly    84 VMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKS 148

Human   131 VVHRDLKPENLLLASKLKGAAVKLADFGLAIEV-EGEQQAWFGFAGTPGYLSPEVLR------KD 188
            :|||||||||:||.   :...||:.|||.|.:: |||:..  ...||||||:||.|:      ..
  Fly   149 IVHRDLKPENILLD---ENHNVKITDFGFAKQLQEGEKLT--NLCGTPGYLAPETLKCNMFEGSP 208

Human   189 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLT 253
            .|.:.||:||||||::.||||.||||...|..:.:.|..|.|.|.||||..::.:.||||.|.|.
  Fly   209 GYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLV 273

Human   254 INPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK--------GAILTTMLAT 310
            ::||:|||..|.|:||:.:....:....|....: ...:.|:|..|:        |.:.::....
  Fly   274 VDPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPI-APAQTNSRHLLQPEASSYRFGQLNSSCAGA 337

Human   311 RNF----SGGKSGGNKKSDGVKKRKSSSSVQL---------MESSESTNTT 348
            .|:    .......|:..||......:|:...         ..:|.:||||
  Fly   338 PNYLYCAPQSSYSSNRMRDGALDDAGASAASATCHVMSPSNASNSYATNTT 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAMK2A	NP_057065.2	STKc_CaMKII	11..302	CDD:270988	116/313 (37%)
		CaMKII_AD	357..484	CDD:285524
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	113/276 (41%)