Protein Alignment CAMK2A and cmk1

DIOPT Version :10

• Sequence 1: NP_057065.2
• Gene: CAMK2A / 815
• HGNCID: 1460
• Length: 489
• Species: Homo sapiens
• Sequence 2: NP_593464.1
• Gene: cmk1 / 2542442
• PomBaseID: SPACUNK12.02C
• Length: 335
• Species: Schizosaccharomyces pombe
• Alignment Length: 318
• Identity: 130/318 - (40%)
• Similarity: 179/318 - (56%)
• Gaps: 20/318 - (6%)

Human    12 EYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLL--KHPNIVR 74
            :|::...||.|.::.||..|.:...:.|||||:| ||:..:....::.|..|.:.:  :||||:.
pombe    30 KYRVGRVLGGGTYATVREAVHIETNKMYAAKIMN-KKMMEKKQDFVKNEIAILKRVSYEHPNILH 93

Human    75 LHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPE 139
            |.|......:.|||.:|.||||||:.|.|:..:.||||:..::....||.:.|..|:||||||||
pombe    94 LVDFFETVNNLYLITELATGGELFDRICAKGSFYEADAAALMRTTTSAVKYLHDNGIVHRDLKPE 158

Human   140 NLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFA-GTPGYLSPEVLRKDPYGKPVDLWACGVIL 203
            |||..||...:.:.:|||||:...|..|......| |||.|::|||.|:..||||||:||.|||.
pombe   159 NLLYRSKDPNSDLLIADFGLSHFYEDSQYYMLMTACGTPEYMAPEVFRRTGYGKPVDMWAIGVIT 223

Human   204 YILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKH 268
            |.||.||.||....|..:.:.|.|..|.|..|.|..::..|||.|.|.|..:||||:|||:||||
pombe   224 YFLLSGYTPFARPSQVEVIEAILANEYTFNDPCWSGISETAKDFIKKCLENDPSKRLTAADALKH 288

Human   269 PWISHRSTVASCMHRQETVDCL----KKFNARRKLKGAILTTMLATRNFSGGKSGGNK 322
            |::|.:        |..|.:.|    :.||||:..:    |...|.|.|:..|...||
pombe   289 PFLSEK--------RPATSNLLPNVRENFNARKTFR----TAYNAVRAFNTWKKLENK 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAMK2A	NP_057065.2	STKc_CaMKII	11..302	CDD:270988	123/296 (42%)
		CaMKII_AD	357..484	CDD:285524
cmk1	NP_593464.1	STKc_CAMK	30..290	CDD:270687	114/260 (44%)