DRSC/TRiP Functional Genomics Resources

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Protein Alignment RSPH6A and Rsph4a

DIOPT Version :10

Sequence 1:NP_110412.1 Gene:RSPH6A / 81492 HGNCID:14241 Length:717 Species:Homo sapiens
Sequence 2:NP_611869.1 Gene:Rsph4a / 37831 FlyBaseID:FBgn0034957 Length:708 Species:Drosophila melanogaster


Alignment Length:655 Identity:196/655 - (29%)
Similarity:301/655 - (45%) Gaps:139/655 - (21%)


- Green bases have known domain annotations that are detailed below.


Human   185 YSAQVPEPEPLELAVQNAKAYLLQTSINCDLSLYEHLVNLLTKILNQRPEDPLSVLESLNRTTQW 249
            ::|:.||...:...:..||:.|.:.|.....:|::||.:::.:::::||.:.:...|..:|..:.
  Fly    70 HNARNPEAPNIGYELNVAKSILQKYSTLSGDNLFDHLSDIIKRVIDERPPNVIDFFEEFSRNVRE 134

Human   250 EWFH-----PKLDTLRDDPEMQPTYKMAEKQKALFTRSGGGTEGEQEMEEEVGETPV-------- 301
            :.||     |......:....:...|:.:..|..:.     .|||..|.|::....:        
  Fly   135 QKFHLPERFPPSGVFDEVRSFRVAKKILQSMKLPYV-----VEGEDLMGEDLSVEDLRTNEDMRI 194

Human   302 -------------PNIMETAFYFEQAGVGLSSDESFRIFLAMKQLVEQQPIHTCRFWGKILGIKR 353
                         ..:.:..||:.|.|..:|:|:.|::..||.:|.....|..|||||.|.|:|.
  Fly   195 VIDDSMRYFVTFNERVQQLQFYWTQCGFSISNDDIFQLASAMNRLQTHPSIMQCRFWGCINGLKA 259

Human   354 SYLVAEVEF-REG--------EEEAEEEEV------------------EEMTEGGEVMEAHGEEE 391
            ||.:.|... ||.        |||..::::                  .|:|.|     .:|.||
  Fly   260 SYYIVEASLTREEIASRLVMMEEEMRQKQIPFPMRKDREDKPPPAHIGPELTPG-----IYGWEE 319

Human   392 GEEDE-EKAVDIVPKSVWKPPPV--------IPKEESRSGANKYLYFVCNEPGLPWTRLPHVTPA 447
            ...:| ||   :.||:.  |.|:        ||.|....|.|:|.|||.|.....|..||.|||.
  Fly   320 FPPEELEK---MKPKAA--PVPLVEEMELYDIPPEFIGKGCNRYSYFVVNSLFDDWIELPIVTPR 379

Human   448 QIVNARKIKKFFTGYLDTPVVSYPPFPGNEANYLRAQIARISAATQVSPLGFYQ----------- 501
            |||.:|:||||.||.|:..|:|||.|||.|.:|||..|.||:|.|.::|:|:|:           
  Fly   380 QIVVSRQIKKFLTGDLEADVISYPCFPGKEKHYLRTLIGRITAGTYIAPVGYYRRMTKKEQRMFD 444

Human   502 -------FSEEEGDEEEEGGAGRDSYEENPD--------FEGIPVLELVDSMANWVHHTQHIL-P 550
                   ..|||.:||||...|.:...|:.|        :|..|:..|...:| |||...:|| .
  Fly   445 GEEEEEGEEEEEEEEEEEFNEGEEEQIEDNDVMLLKNEKYEAEPLGSLATPVA-WVHVRSNILNQ 508

Human   551 QGRCTWVN----------------PLQKTEEEEDLGEEEEKADEGPEEVEQ----------EVGP 589
            |||..|.:                .:|...|.|:..||||..:||.||.|:          |:||
  Fly   509 QGRVVWYDEEKARKEREKALALYLKMQMLGEMEEEVEEEEDEEEGEEEGEEEGMIEGFNQPELGP 573

Human   590 PLLTPLSEDAEIMHLAPWTTRLSCSLCPQYS-VAVVRSNLWPGAYAYASGKKFENIYIGWGHKYS 653
            .:|:..:.|........|..|::.....|.. :.|::||:|||||.:...|..|:||:||||||.
  Fly   574 SILSSCANDMNPEVPVSWLARMTSKYTNQKERMLVMQSNVWPGAYTFIFEKTCESIYLGWGHKYY 638

Human   654 PESFNPALPAP-IQQEYPSGPE-IMEMSDPTVEEEQALKA----AQEQALGATEEEEEGEEEEEG 712
            ..:. |....| :|:|:|..|| .:|.:|||||||:|.||    .|::|....|:.|:.:::|..
  Fly   639 ARNI-PFKHLPMVQEEFPHNPEDFVEANDPTVEEEEAYKAWLLRKQQKAEYVAEDIEDYDDDEFA 702

Human   713 EETDD 717
            ::.||
  Fly   703 DQYDD 707

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RSPH6ANP_110412.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..65
Radial_spoke 202..652 CDD:461405 166/565 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 503..523 8/19 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 563..588 12/34 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 672..717 18/49 (37%)
Rsph4aNP_611869.1 Radial_spoke 87..637 CDD:461405 166/565 (29%)
Blue background indicates that the domain is not in the aligned region.

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