DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TAF15 and taf15

DIOPT Version :9

Sequence 1:	NP_631961.1	Gene:	TAF15 / 8148	HGNCID:	11547	Length:	592	Species:	Homo sapiens
Sequence 2:	NP_001004806.1	Gene:	taf15 / 448047	XenbaseID:	XB-GENE-984011	Length:	501	Species:	Xenopus tropicalis

Alignment Length:	669	Identity:	298/669 - (44%)
Similarity:	337/669 - (50%)	Gaps:	248/669 - (37%)

- Green bases have known domain annotations that are detailed below.

Human     2 SDSGSYGQSGG--EQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYGQNYSGYSS-YGQSQSGY 63
            ||..|||..||  :||||..||:.|:|..||.||.|||||||.:.|   :|.|||| |||..||.
Frog     3 SDPSSYGGYGGGQQQQSYPGYGSQGNQNSGQPSQIYSGYGQTAEQS---SYGGYSSGYGQGHSGL 64

Human    64 SQSYGGYENQKQSSY---SQQPYNNQGQQQNMESSGSQGGR----------APSYDQPDYG---- 111
            :|...|     |||.   :||.|.|.| ||..:|.|..|||          ..||||..||
Frog    65 AQPLQG-----QSSTGHDNQQSYGNYG-QQGADSRGGYGGRFDTQSSGQQQQDSYDQHGYGQKQR 123

Human   112 -------QQDSYDQ-------QSGYDQ--HQGSYD---------------------EQSNYDQ-- 137
                   ||.|.||       :|||.:  .||.||                     :|..|.|
Frog   124 IGYGETPQQGSLDQPGHGQKPRSGYGEQPQQGPYDQPGYGQKERPGYGEQPQQGSSDQPGYGQKQ 188

Human   138 -QHDSYSQ----NQQSYHSQRENYSH-HTQDDRRDVSRYGEDNRGYGGSQ--GGGRGRGGYDKDG 194
             |...|.|    .||||.|::|.|.| |.:|||||..|||.| |||||:|  ||||||||:|.:.
Frog   189 SQQGRYDQTGGFEQQSYQSRKEGYGHSHQEDDRRDSGRYGGD-RGYGGAQGFGGGRGRGGFDSER 252

Human   195 RGPMTGSSGGDRGGFKNFGGHRDYGPRTDADSESDNSDNNTIFVQGLGEGVSTDQVGEFFKQIGI 259
            ||...|.|||||||.|||||.||||.:.|.| :.||||||||||||:||..:.||:.::||||||
Frog   253 RGYQGGMSGGDRGGSKNFGGPRDYGSKQDND-DQDNSDNNTIFVQGMGEDATQDQISDYFKQIGI 316

Human   260 IKTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEFHGNIIKVSFATRRPEF 324
            ||.|||||||||||||||:|||.||||||||||||||||||:|||||.|..|:||||||||||||
Frog   317 IKINKKTGKPMINLYTDKETGKSKGEATVSFDDPPSAKAAIEWFDGKMFLDNVIKVSFATRRPEF 381

Human   325 MRGG-------GSGGGRRG----RGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQ 378
            ||||       |.||||||    .||:.|||.::|.||.|::||||||||||||:|||||:||||
Frog   382 MRGGAGGGGGAGGGGGRRGGGHRGGGFGGRGSYRGGGGGPQNGDWVCPNPSCGNVNFARRDSCNQ 446

Human   379 CNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSG 443
            |:||||||||
Frog   447 CSEPRPEDSR------------------------------------------------------- 456

Human   444 GGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGY 508

Frog   457 ----------------------------------------------------------------- 456

Human   509 GGDRGGYGGDRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGY 573
                         :||||.||||||||                        |.||.|.||  ||:
Frog   457 -------------HGGDRGRGGYGGDR------------------------GFRGRGRGG--GGF 482

Human   574 GGKMGGRNDYRNDQRNRPY 592
            |||||||||:|:|||||||
Frog   483 GGKMGGRNDFRSDQRNRPY 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TAF15	NP_631961.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..237		139/301 (46%)
		G_path_suppress	<1..124	CDD:318248	68/155 (44%)
		RRM	136..>315	CDD:330708	126/188 (67%)
		RRM_FUS_TAF15	232..317	CDD:240979	67/84 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..356		21/42 (50%)
		zf-RanBP	354..384	CDD:279035	24/29 (83%)
		RanBP2-type Zn finger	358..379	CDD:275375	18/20 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..592		49/218 (22%)
		21 X approximate tandem repeats of D-R-[S,G](0,3)-G-G-Y-G-G	407..575		20/167 (12%)
taf15	NP_001004806.1	dnaA	76..>220	CDD:237605	45/144 (31%)
		RRM_SF	292..374	CDD:388407	64/81 (79%)
		ZnF_RBZ	424..450	CDD:197784	22/25 (88%)
		RanBP2-type Zn finger	426..447	CDD:275376	18/20 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H131088
Inparanoid	1	1.050	476	1.000	Inparanoid score	I8012
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1539664at2759
OrthoFinder	1	1.000	-	-		FOG0002238
OrthoInspector	1	1.000	-	-		oto151513
Panther	1	1.100	-	-	LDO	PTHR23238
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X712
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.160