DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAMK4 and CMK2

DIOPT Version :9

Sequence 1:	NP_001310303.1	Gene:	CAMK4 / 814	HGNCID:	1464	Length:	473	Species:	Homo sapiens
Sequence 2:	NP_014626.1	Gene:	CMK2 / 854144	SGDID:	S000005376	Length:	447	Species:	Saccharomyces cerevisiae

Alignment Length:	403	Identity:	133/403 - (33%)
Similarity:	215/403 - (53%)	Gaps:	40/403 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    52 LGRGATSIVYRCKQKGTQKPYALKVLKK------TVDKKIVRTEIGVLLRLSHPNIIKLKEIFET 110
            ||.|:..:|.:.::..|.:..|:|:|.|      .|..:::..|:.:|.:||||||:..|:.||:
Yeast    53 LGAGSFGVVRQARKLSTNEDVAIKILLKKALQGNNVQLQMLYEELSILQKLSHPNIVSFKDWFES 117

Human   111 PTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATP 175
            ..:..:|.:|.|||||||||:.:|.::|.||.:.:.|||.||.|:|...:|||||||||:||...
Yeast   118 KDKFYIVTQLATGGELFDRILSRGKFTEVDAVEIIVQILGAVEYMHSKNVVHRDLKPENVLYVDK 182

Human   176 APDAPLKIADFGLSKIVE-HQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFE 239
            :.::||.|||||::|.:: .:.|:....|:.||.|||:|....:|...|:||:|:|||.||||:.
Yeast   183 SENSPLVIADFGIAKQLKGEEDLIYKAAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLCGYS 247

Human   240 PFYDERGDQFMFRRILNCEY--YFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTG 302
            ||..|..:.|| .......|  .|..|:||.:|::.|..:.|.:.|:|..|.|..:.|..||:|.
Yeast   248 PFIAESVEGFM-EECTASRYPVTFHMPYWDNISIDVKRFILKALRLNPADRPTATELLDDPWITS 311

Human   303 KAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPSPI-QDGN 366
            |.....::....||  .|:.|:||:.|::.|..::|:              |..|:...: .||:
Yeast   312 KRVETSNILPDVKK--GFSLRKKLRDAIEIVKLNNRI--------------KRLRNMYSLGDDGD 360

Human   367 EDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKAVEDG----IKV 427
            .|::.....|.:. ||...::...:.:..|       ||.:: .||..|:.....:|.    :|.
Yeast   361 NDIEENSLNESLL-DGVTHSLDDLRLQSQK-------KGGEL-TEEQMKLKSALTKDAFVQIVKA 416

Human   428 ADLELEEGLAEEK 440
            |.....:.||.|:
Yeast   417 ATKNKHKVLAGEE 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAMK4	NP_001310303.1	STKc_CaMKIV	42..335	CDD:270987	112/291 (38%)
		Pkinase	46..300	CDD:278497	101/256 (39%)
		Autoinhibitory domain	305..321		2/15 (13%)
		PP2A-binding	306..323		3/16 (19%)
		Calmodulin-binding. /evidence=ECO:0000255	322..341		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..368		4/27 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..473
CMK2	NP_014626.1	STKc_CAMK	46..308	CDD:270687	100/255 (39%)
CMK2	NP_014626.1	S_TKc	47..309	CDD:214567	101/256 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	231	1.000	Domainoid score	I462
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I804
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000163
OrthoInspector	1	1.000	-	-		mtm10138
orthoMCL	1	0.900	-	-		OOG6_100153
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.760