DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAMK4 and CG10177

DIOPT Version :9

Sequence 1:	NP_001310303.1	Gene:	CAMK4 / 814	HGNCID:	1464	Length:	473	Species:	Homo sapiens
Sequence 2:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster

Alignment Length:	270	Identity:	77/270 - (28%)
Similarity:	132/270 - (48%)	Gaps:	17/270 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    40 DALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTV---DKKIVRTEIGVLLRL-SHPN 100
            :|:..:.|....:.....:::||.:.:..:....:|::.|..   |:.....|..||.:| ||||
  Fly   143 EAIQLYIETIEPVEHNTRTLIYRGQTRANRTKCTVKMVNKQTQSNDRGDTYMEAEVLRQLQSHPN 207

Human   101 IIKLKEIFETPTEISLVLELVTGGELFDRIVEK-GYYSERDAADAVKQILEAVAYLHENGIVHRD 164
            ||:|....|....:..|||.:...  ..::::| |..||.||...::..:.|:|::|:..::|||
  Fly   208 IIELMYTVEDERYMYTVLEHLDCN--MQKVIQKRGILSEADARSVMRCTVSALAHMHQLQVIHRD 270

Human   165 LKPENLLYATPAPD---APLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWS 226
            :||||||..:.:..   ..:|:|:|.|:.......|. ..||||.|.|||::....|..:||.||
  Fly   271 IKPENLLVCSSSGKWNFKMVKVANFDLATYYRGSKLY-VRCGTPCYMAPEMIAMSGYDYQVDSWS 334

Human   227 VGIITYILLCGFEPFYDE-RGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKR-- 288
            :|:..:.:|||..||... :..:.::..|::....:.......:|..|..|:..|:|.||..|
  Fly   335 LGVTLFYMLCGKMPFASACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPSYRVP 399

Human   289 ---LTTFQAL 295
               |..||.|
  Fly   400 IAELDKFQFL 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAMK4	NP_001310303.1	STKc_CaMKIV	42..335	CDD:270987	76/268 (28%)
		Pkinase	46..300	CDD:278497	76/264 (29%)
		Autoinhibitory domain	305..321
		PP2A-binding	306..323
		Calmodulin-binding. /evidence=ECO:0000255	322..341
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..473
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	74/247 (30%)
		PKc_like	164..403	CDD:304357	71/241 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900