DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAMK4 and lok

DIOPT Version :9

Sequence 1:	NP_001310303.1	Gene:	CAMK4 / 814	HGNCID:	1464	Length:	473	Species:	Homo sapiens
Sequence 2:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster

Alignment Length:	301	Identity:	100/301 - (33%)
Similarity:	164/301 - (54%)	Gaps:	22/301 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    40 DALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTV-----------DKKIVRTEIGVL 93
            :.::..:.|..:||.||..:|.......|.:.:|:|::||.:           |...|..|..::
  Fly   168 EEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIM 232

Human    94 LRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
            ..||||.::::.:|.:.|..:.:|||.:.||:|.:||:.....||..:.....|:..||.|||:.
  Fly   233 KNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDR 297

Human   159 GIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEIL----RGCAYG 219
            ||.||||||:|:|..|...:..||::||||||.|:...:|:|:||||.|.|||:|    |. ||.
  Fly   298 GITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGRE-AYT 361

Human   220 PEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLD 284
            .:||:||:|::.:..|.|..||.||.|.. ..::|....:.:..|.|..||..||.|:.:::::|
  Fly   362 KKVDIWSLGVVLFTCLSGTLPFSDEYGTP-AAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVD 425

Human   285 PKKRLTTFQALQHPWVTG-----KAANFVHMDTAQKKLQEF 320
            |::|.:....||..|:..     ||...:.:|..:.:.:.|
  Fly   426 PERRPSIDDVLQSSWLRDAPMLQKAKRLMKLDGMEIEEENF 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAMK4	NP_001310303.1	STKc_CaMKIV	42..335	CDD:270987	100/299 (33%)
		Pkinase	46..300	CDD:278497	95/268 (35%)
		Autoinhibitory domain	305..321		2/16 (13%)
		PP2A-binding	306..323		2/15 (13%)
		Calmodulin-binding. /evidence=ECO:0000255	322..341
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..473
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	95/274 (35%)
		S_TKc	174..441	CDD:214567	95/268 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910