DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAMK4 and cmk1

DIOPT Version :9

Sequence 1:	NP_001310303.1	Gene:	CAMK4 / 814	HGNCID:	1464	Length:	473	Species:	Homo sapiens
Sequence 2:	NP_593464.1	Gene:	cmk1 / 2542442	PomBaseID:	SPACUNK12.02c	Length:	335	Species:	Schizosaccharomyces pombe

Alignment Length:	338	Identity:	142/338 - (42%)
Similarity:	189/338 - (55%)	Gaps:	23/338 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    23 PGTASL---VPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVL-KKTVDK 83
            |.|::|   .|...:|  .:..|...:.|...||.|..:.|.......|.|.||.|:: ||.::|
pombe     7 PNTSALKDGAPKATVD--QKQLLPCKYRVGRVLGGGTYATVREAVHIETNKMYAAKIMNKKMMEK 69

Human    84 K--IVRTEIGVLLRLS--HPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADA 144
            |  .|:.||.:|.|:|  ||||:.|.:.|||...:.|:.||.|||||||||..||.:.|.|||..
pombe    70 KQDFVKNEIAILKRVSYEHPNILHLVDFFETVNNLYLITELATGGELFDRICAKGSFYEADAAAL 134

Human   145 VKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVE--HQVLMKTVCGTPGY 207
            ::....||.|||:|||||||||||||||.:..|::.|.|||||||...|  ...::.|.||||.|
pombe   135 MRTTTSAVKYLHDNGIVHRDLKPENLLYRSKDPNSDLLIADFGLSHFYEDSQYYMLMTACGTPEY 199

Human   208 CAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSL 271
            .|||:.|...||..||||::|:|||.||.|:.||  .|..|. :...||..||.|..|.|..:|.
pombe   200 MAPEVFRRTGYGKPVDMWAIGVITYFLLSGYTPF--ARPSQVEVIEAILANEYTFNDPCWSGISE 262

Human   272 NAKDLVRKLIVLDPKKRLTTFQALQHPWVTGK---AANFVHMDTAQKKLQEFNARRKLKAAVKAV 333
            .|||.::|.:..||.||||...||:||:::.|   .:|.:     ....:.||||:..:.|..||
pombe   263 TAKDFIKKCLENDPSKRLTAADALKHPFLSEKRPATSNLL-----PNVRENFNARKTFRTAYNAV 322

Human   334 VASSRLGSASSSH 346
            .|.:......:.|
pombe   323 RAFNTWKKLENKH 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAMK4	NP_001310303.1	STKc_CaMKIV	42..335	CDD:270987	135/303 (45%)
		Pkinase	46..300	CDD:278497	125/261 (48%)
		Autoinhibitory domain	305..321		1/15 (7%)
		PP2A-binding	306..323		3/16 (19%)
		Calmodulin-binding. /evidence=ECO:0000255	322..341		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..368		1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..473
cmk1	NP_593464.1	STKc_CAMK	30..290	CDD:270687	124/261 (48%)
cmk1	NP_593464.1	S_TKc	31..291	CDD:214567	125/261 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	245	1.000	Domainoid score	I479
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000163
OrthoInspector	1	1.000	-	-		otm53609
orthoMCL	1	0.900	-	-		OOG6_100153
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.710