Protein Alignment NPRL3 and NPR3

DIOPT Version :10

• Sequence 1: NP_001070818.1
• Gene: NPRL3 / 8131
• HGNCID: 14124
• Length: 569
• Species: Homo sapiens
• Sequence 2: NP_011840.1
• Gene: NPR3 / 856362
• SGDID: S000001015
• Length: 1146
• Species: Saccharomyces cerevisiae
• Alignment Length: 890
• Identity: 160/890 - (17%)
• Similarity: 268/890 - (30%)
• Gaps: 373/890 - (41%)

Human    15 SGSRGNKLLFRYPFQRSQEHPASQTSKPRSRYAASNTGDHADE---------------------- 57
            |..:||||| :.....:..:..:.:....|:.:.|:||:|..|
Yeast   281 STKKGNKLL-KNTSNETDGNAFTGSCSISSKKSLSSTGEHNQELRNSSLNDTPGQSPHHYHHRYH 344

Human    58 ------------------------------QDG----------DSRFSDV---------ILATIL 73
                                          |||          :..|.|:         .:|...
Yeast   345 HYHKNAATSQRNSHTQYDVEEEDMEVSAMLQDGKISMNEIFFEEENFQDINKILEFDNDFVAEFC 409

Human    74 ATKSEMCGQKFELKIDNVRFVGHP----------------------------------------- 97
            :.:.|||..:||..:||..|:|.|
Yeast   410 SPEREMCNTRFEFTVDNFCFLGLPIHVDSQGRWRKSKHKNKTRSKRSSSTTTNISRKKSIASKIS 474

Human    98 ----------------TLLQHALGQISKTDPSP-------------KRE----APTMILFNVVFA 129
                            |:....:|..:.|| :|             :||    ...|.:|:|.|.
Yeast   475 SLSENTLKKVNSGEADTVYDSNIGHEASTD-TPNLRINTDVSGNEFEREKEDLGKNMNMFHVCFV 538

Human   130 LRANADPSVINCLHNLS-------RRIATVLQHEERRCQYLTREAKLILALQDEV--------SA 179
            :    :|.:|.....:.       .|::.:|::.:.:..|::.|..:||..::.|        |.
Yeast   539 M----NPHLIEYNKRIDDMYQFVVTRLSLLLRYVQSKTSYISSECHIILKEKERVLKHSKTYQSI 599

Human   180 MADGNEGPQSPFHHILPKCKLARDLKEAYDSLCTSGVVRLHINSWLEVSFCLPHKIHYA------ 238
            ...||:| :..:..||.|..|||.|.|..|.:..:.:..|.||....:|..:|.:..:.
Yeast   600 RGAGNKG-KYLYQRILAKSSLARALTECVDKIQRNEIACLEINDDKVISLQIPIQNEFEKMPNFK 663

Human   239 ---------ASSLIPPEAIERSLKAIRPY------------------------------------ 258
                     .:|::..:.:|:|...|...
Yeast   664 LQPVLRGSYLTSILNMKFLEKSSLRIESQNRQNDQAQFSDTNNNIYRFGNNINSTGHCGAANVDD 728

Human   259 ------------------HALLLLSDEKSLLGELPI-----DCSPA----LVRVIKTTSAVKNLQ 296
                              :|||||.:..:::..|..     |....    |||.|:....:::.:
Yeast   729 GDDNESNYYCDDNDDLLNYALLLLDEPNNIISSLETFSYQDDIGTIILKHLVRNIQPNIPLRSYR 793

Human   297 QLAQDA--------DL---------ALLQVFQLAAHLVYWGKAIIIYPLCENNVYMLSPNASVCL 344
            .|..|.        ||         ::|:  ..|.||:||..|.|:.||.....|::||.|.:..
Yeast   794 YLITDLLDNPSSLDDLTTETNSLESSILR--SCALHLMYWRHARIVIPLSSKYTYIVSPLAPIQG 856

Human   345 YS------------------------------PLAEQ----FSHQFPSHDLPSVLAKFSLPVSLS 375
            |:                              ||..|    |..:|||  ||      |||:.||
Yeast   857 YTIDDYKSTSQNDGNVKKMDDRENNKSGSDRVPLIYQNSMLFRSKFPS--LP------SLPIFLS 913

Human   376 --------EFRNPLAPAVQETQLIQMVVWMLQRRLLIQLHTYVCL-------MASPSEEEP---- 421
                    .:.|.:.....:...:..:.|::|...:.||.|::.:       ||...:.|.
Yeast   914 LLSTDKPQAYSNIIPSREHKPVYLNALAWLIQYGYVTQLLTFINIRVDKHIKMAVDEDLEKEGFR 978

Human   422 ------RPRED----DVPFTARVG-GRSLSTPNALS-FGSPTSSDDMTLTSPSMDNSSAELLPSG 474
                  ||..|    |.......| .|..:...|.| ......|:|........||.:
Yeast   979 KTNTARRPSMDYKKTDKKLDDEDGQSRDANASEACSGKNEGMQSNDNNKDVDEKDNEN------- 1036

Human   475 DSPLNQRMTENLLASLSE--------------HERAAILSVPAAQ-------------NPEDLR- 511
            ||.::.| .:|.:|...|              |:...||....|.             .|.|::
Yeast  1037 DSRVDDR-DDNEIAIADEEEILHFEYDDPEMQHDYTIILEPERATAIEKRWLYRCIYGQPSDIQI 1100

Human   512 MFARLLHYFRGRHHLEEIMYNENTRRSQLLMLFDKFRSVLVVTTH 556
            :|.:||.||.|:..:|.::..|...|..|..|.:.....|:...|
Yeast  1101 LFNKLLKYFNGKVPMELVIIKEEISRHDLKKLLNALDKYLIEIHH 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPRL3	NP_001070818.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..60		7/84 (8%)
		NPR3	64..416	CDD:451662	107/593 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	416..477		14/76 (18%)
NPR3	NP_011840.1	NPR3	400..966	CDD:427435	103/581 (18%)