Protein Alignment NPRL3 and Nprl3

DIOPT Version :10

• Sequence 1: NP_001070818.1
• Gene: NPRL3 / 8131
• HGNCID: 14124
• Length: 569
• Species: Homo sapiens
• Sequence 2: NP_648680.2
• Gene: Nprl3 / 39550
• FlyBaseID: FBgn0036397
• Length: 610
• Species: Drosophila melanogaster
• Alignment Length: 633
• Identity: 235/633 - (37%)
• Similarity: 340/633 - (53%)
• Gaps: 100/633 - (15%)

Human     1 MRDNTSPISVILVSSGSRGNKLLFRYPFQR-SQEHPAS---QTSKPRSRYAASNTGD------H- 54
            |..|.:|::||||...|:|::||:|||:|. .|...|:   :.|:.|:.||.:||.|      |
  Fly     1 METNVNPLAVILVYFDSKGDRLLYRYPYQTLGQTEVANDEQRKSRKRNPYAVANTDDLLQTPTHL 65

Human    55 --ADEQDGDSRFSDVILATILATKSEMCGQKFELKIDNVRFVGHPTLLQHALGQISKTDPSPKRE 117
              |..|.....|:|.:|:.:.|.|.::|.||||||:::||||.||||:..   :..::.|..|::
  Fly    66 GAAKSQGQLQGFADEVLSALFAVKPQLCNQKFELKLNDVRFVSHPTLIPQ---KEQRSGPMAKQQ 127

Human   118 APTMILFNVVFALRANADPSVINCLHNLSRRIATVLQHEERRCQYLTREAKLILALQDEVSAMAD 182
                :|.|:||||.|.|..|::.|.|.||:|:...|:.||:|..|||.:...:....||..
  Fly   128 ----MLINIVFALHAQASYSIVKCYHELSKRLGLALKFEEQRSGYLTEQTAQMARTHDEQQ---- 184

Human   183 GNEGPQSPFHH----ILPKCKLARDLKEAYDSLCTSGVVRLHINSWLEVSFCLPHKIH--YAASS 241
                 |.|...    |..:|.||:.|:..:..|||:|::...:|..|.:.||||.|.|  :...|
  Fly   185 -----QQPLERTLELIAERCSLAQALRSIFHDLCTTGLLSTSLNHNLTLCFCLPAKAHQLHKKGS 244

Human   242 LIPPEAIERSLKAIRPYHALLLLSDEKSLLGELPIDCSP-----ALVRVIKTTSAVKNLQQLAQD 301
            ::.||.|:|.|:|::|||.:|||.|...||     ||.|     .|.:::.....:.:||.::.:
  Fly   245 MVDPETIDRCLRALKPYHGMLLLVDFAELL-----DCVPPTGARMLWQLVDVYDPLISLQSMSSN 304

Human   302 ADLALLQVFQLAAHLVYWGKAIIIYPLCENNVYMLSPNASVCLYSPLAEQFSHQFPSHDLPSVLA 366
            |||::..|::|.:|||||.||.|||||||.|||:::|:|.:...|.|.|:||.:|....|..|::
  Fly   305 ADLSIEHVYKLVSHLVYWAKATIIYPLCETNVYVIAPDAPLHTKSHLVEKFSARFAGMSLFEVIS 369

Human   367 KFSLPVSLSEFRNPLAPAVQETQLIQMVVWMLQRRLLIQLHTYVCLMASPSEEE----------- 420
            .||||.|:.....||....::..|.|||:||||..||:||||||..|  |||:|
  Fly   370 DFSLPTSIGHLTTPLQQPARQGILAQMVIWMLQHHLLMQLHTYVQFM--PSEDEFGDSASCSNHL 432

Human   421 ----------PRPREDD--------------VPFTARVGGR---------SLSTPNALSFGSPTS 452
                      ..|..|:              || ...|||.         ||::.|.....|.:.
  Fly   433 RDAISDEEGDQEPDADELHGSMLSMSSHPLPVP-AVLVGGHRREASEDHSSLASDNIAVQPSSSH 496

Human   453 SDDMTLT-SPSMDNSSAELLPSGDSPLNQRMTENLLASLSEHERAAILSVPAAQNPEDLRMFARL 516
            ..:.::| |.|.||..     |.||..:::..:.||...|:.:||||..:||:.|.:||.:..:|
  Fly   497 KSNFSITASMSTDNCD-----SLDSMEDEQKLKELLQVFSDADRAAIRRIPASANVDDLSLLVKL 556

Human   517 --LHYFRGRHHLEEIMYNENTRRSQLLMLFDKFRSVLVVTTHEDPVIA 562
              :.||:..||||||||.||.||||||.|.||||.||::...|||.||
  Fly   557 YQMGYFKSEHHLEEIMYFENLRRSQLLQLLDKFRDVLIIYETEDPAIA 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPRL3	NP_001070818.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..60		14/45 (31%)
		NPR3	64..416	CDD:451662	142/362 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	416..477		22/105 (21%)
Nprl3	NP_648680.2	NPR3	76..413	CDD:451662	139/357 (39%)