Protein Alignment NPRL3 and npr3

DIOPT Version :10

• Sequence 1: NP_001070818.1
• Gene: NPRL3 / 8131
• HGNCID: 14124
• Length: 569
• Species: Homo sapiens
• Sequence 2: NP_001342971.1
• Gene: npr3 / 2541073
• PomBaseID: SPBC543.04
• Length: 585
• Species: Schizosaccharomyces pombe
• Alignment Length: 639
• Identity: 140/639 - (21%)
• Similarity: 250/639 - (39%)
• Gaps: 161/639 - (25%)

Human     8 ISVILVSSGSRGNKLLFRYPFQRSQEHPASQTSKPRSRYAAS-NTGDHA---------DEQDGD- 61
            :::.||...:.|...:|.:|.|            |:.|..|: :..|.|         |:.|.|
pombe     9 VAIFLVEKTTSGANFVFHWPLQ------------PQVRLQATHHNNDSAESAIGMLDLDDSDDDE 61

Human    62 -SRFSDV------------ILATILATKSEMCGQKFELKIDNVRFVGHPTLL------------- 100
             :||::|            .||.:|:.:.|:|.||||:.:|.:.|:|.|..:
pombe    62 NNRFTEVADDTHVLGYEKGFLANMLSPRIELCNQKFEIWVDGLTFLGCPVHIGPNGEWAKRRKPR 126

Human   101 ---------QHALGQISKTDP---------SPKREAPTMILFNVVFALRANA----DPSVINCLH 143
                     .|.:.:...:.|         |..:...:|.||:|||.|....    .|:|.....
pombe   127 TTVESNASSSHLVSKPESSHPSTGSFEVKSSSSKSRSSMSLFHVVFVLNVPTATVYRPTVNTMYD 191

Human   144 NLSRRIATVLQHEERRCQYLTREAKLILALQDEVSAMADGNEGPQSPF--------HHILPKCKL 200
            ::..::.|.|::|:.:..|:..|...||.|.::.|:.       ..||        ||    ..|
pombe   192 HIVVKLVTGLKYEQAKRNYVENECIHILKLTEKYSSQ-------NVPFDVYAAQIPHH----SNL 245

Human   201 ARDLKEAYDSLCTSGVVRLHINSWLEVSFCLP----------HKIHYAASSLIP---------PE 246
            |..|...|::|.......|.||..:.:|...|          :::....|:::.         |.
pombe   246 ASVLATTYEALINMHTAYLEINQSINLSLLWPMSVSTNTLENYELQVRPSTILASQTIFSEEHPS 310

Human   247 AIERSLKAIRPYHALLLLSDEKSLLGELPIDCSPALVRVIKTTSAVKNLQQLAQDADLALLQVFQ 311
            :||   ..:.||..||||.|..:::..:|:..:..|...|...........:|....:::.:.|.
pombe   311 SIE---PFVAPYWTLLLLKDTDTIMKRVPLLQNSLLSSFIAIVKPNLTFTDIANRLGISVSECFI 372

Human   312 LAAHLVYWGKAIIIYPLCENNVYMLSPNASVCLYSPLAEQFSHQFPSHDLPSVLAKFSLPVSLSE 376
            ||.||::|.|||.|.||...|.|:.||.|::......::.|..:|||  ||| |:.|   :::..
pombe   373 LAKHLIHWRKAIAIPPLLIRNTYVTSPTANLFNLEEESKLFKKEFPS--LPS-LSTF---LAILS 431

Human   377 FR-NPLAPAV----QETQLIQMVVWMLQRRLLIQLHTYVCLMASPSEEEPRPREDDVPFTARVGG 436
            |: .|.|..:    .|...::|:.|:.:|..:.:.:.|:.::. |.|.:.:
pombe   432 FKPRPFASIIPSKDHELVYLEMLAWLCRRNWVYEQNIYMYILV-PEEIKKK-------------- 481

Human   437 RSLSTPNALSFGSPTSSDDMTLTSP-SMDNSSAELL--PSGDSPLNQRMTENLLASLSEHERAAI 498
                 ..||.....:|.:||.|... ..||....::  |...|.|.|:..:     :..:||
pombe   482 -----AIALIESDESSKNDMQLRKQLEQDNGKESIIIDPHSASLLEQKWIQ-----IIAYER--- 533

Human   499 LSVPAAQNPEDLRMFARLLHYFRGRHHLEEIMYNENTRRSQLLMLFDKFRSVLV 552
                   .||...:|..::.|..||..|:.|...|...|..:..:.:::...::
pombe   534 -------GPEMAPLFTSIVKYLNGRFALQTIWVAEGLPRKLMRNILNEYNDYIL 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPRL3	NP_001070818.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..60		8/42 (19%)
		NPR3	64..416	CDD:451662	99/430 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	416..477		11/63 (17%)
npr3	NP_001342971.1	NPR3	76..480	CDD:427435	99/424 (23%)