Protein Alignment NPRL3 and nprl-3

DIOPT Version :10

• Sequence 1: NP_001070818.1
• Gene: NPRL3 / 8131
• HGNCID: 14124
• Length: 569
• Species: Homo sapiens
• Sequence 2: NP_501396.1
• Gene: nprl-3 / 185331
• WormBaseID: WBGene00018072
• Length: 511
• Species: Caenorhabditis elegans
• Alignment Length: 580
• Identity: 141/580 - (24%)
• Similarity: 247/580 - (42%)
• Gaps: 118/580 - (20%)

Human     9 SVILVSSGSRGNKLLFRYPFQRSQEHPASQTSKPRSRYAASNTGDHA--------DEQDG----D 61
            :|:...:|..|.|::..||.::    ||::......:.::||.|...        |...|    |
 Worm    16 AVMCFLTGQSGEKIVSIYPHRK----PATKAPSKDPQPSSSNPGQCVKPVLTSVKDPSYGFGRVD 76

Human    62 SRF--SDVILATILATKSEMCGQKFELKIDNVRFVGHPTLLQHALGQISKTDPSPKREAPTMILF 124
            :.|  |..:||.:..|:...|...|::||:|.|||.:|           ||..:  |...|....
 Worm    77 TEFDMSLGMLAYVFKTQEIACNDGFDMKINNQRFVAYP-----------KTWKA--RGESTNYQI 128

Human   125 NVVFALRANADPSVINCLHNLSRRIATVLQHEERRCQYLTREAKLILALQDEVSAMADGNEGPQS 189
            ::||||:...:....:....||.:||..|...:....:|.||.|           .||..|.|..
 Worm   129 SIVFALKNGCEQHTASAYQTLSNKIAVSLVMLQNYFGFLEREDK-----------WADNAEEPNK 182

Human   190 --PFHHILPKCKLARDLKEAYDSLCTSGVVRLHINSWLEVSFCLPHKIHYAASSLIPP---EAIE 249
              |.........:.:.|.|.::.:...|.:..::.:::|:.||  .:.|......:.|   :.|:
 Worm   183 DHPLEEFAKTSFIVQPLAEMFEEVRNRGNIHKYLINFVELGFC--DEAHALTKLNVVPKGRQEID 245

Human   250 RSLKAIRPYHALLLLSDEKSLLGELPIDCSPALVRVIKTTSAVKNLQQLAQDADLALLQVFQLAA 314
            ..::.::|||.:|||.|    :...| |.:|.:.:::...|..:::..::..:.:.:.:||.:..
 Worm   246 EIVRKMKPYHGILLLED----VWPTP-DANPIVAKLLSHCSPDRSILDMSTASGIPIFEVFMIIR 305

Human   315 HLVYWGKAIIIYPLCENNVY--MLSPNASVCLYSPLAEQFSHQFPS--HDLPSVLAKFSLPVSLS 375
            ||:.|.:||:|||||..|:|  ..||..    ...:||:|:.||.:  | |.:.||.|:.|.:|.
 Worm   306 HLLQWTRAILIYPLCNTNIYTSATSPQP----LDKMAEKFTAQFGNTIH-LAAGLAHFNPPKTLD 365

Human   376 EFRNPLAPAVQETQLIQMVVWMLQRRLLIQLHTYVCLMAS------PSEEEPRPREDDVPFTARV 434
            .|.....|..::....::||.:|:.::|:|||.:..::..      |..:||.|.|    ||..:
 Worm   366 TFIRKNLPLHEQGVRAKLVVALLRHQMLMQLHQFYYILKPYSIAILPEPKEPCPAE----FTKII 426

Human   435 GGRSLSTPNALSFGSPTSSDDMTLTSPSMDNSSAELLPSGDSPLNQRMTENLLASLSEHERAAIL 499
            ...:|  ||.:              ...:.:..||:|                      |..:..
 Worm   427 EESTL--PNDV--------------KGVVADICAEML----------------------ETTSYA 453

Human   500 SVPAAQNPEDLRMFARLLHYFRGRHHLEEIMYNENTRRSQLLMLFDKFRSVLVVTTHEDP 559
            ||     ...|.:|.::.....|.||||||.|..|..|:::..:|..|:  ||:.|...|
 Worm   454 SV-----KRTLSLFVKVAPMMDGNHHLEEIKYKNNLDRTEIEGVFVSFK--LVIATFRRP 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPRL3	NP_001070818.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..60		7/40 (18%)
		NPR3	64..416	CDD:451662	93/368 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	416..477		13/60 (22%)
nprl-3	NP_501396.1	NPR3	<251..402	CDD:451662	48/160 (30%)