DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CALU and CG31650

DIOPT Version :9

Sequence 1:	NP_001186600.1	Gene:	CALU / 813	HGNCID:	1458	Length:	323	Species:	Homo sapiens
Sequence 2:	NP_001162879.1	Gene:	CG31650 / 326150	FlyBaseID:	FBgn0031673	Length:	342	Species:	Drosophila melanogaster

Alignment Length:	347	Identity:	120/347 - (34%)
Similarity:	187/347 - (53%)	Gaps:	51/347 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    15 LMCLSLCT--------------AFALSKPTEK---KDRV----------HHEPQLSDKVHNDAQS 52
            |:.|:||.              |.|.|...||   |:||          ||..:  |..||
  Fly     7 LLPLTLCAVALLAAVGPMPAHGAVANSHKHEKHLSKERVKDGIYAPRDAHHHGE--DGEHN---- 65

Human    53 FDYDHDAFLG-AEEAKTFDQLTPEESKERLGKIVSKIDGDKDGFVTVDELKDWIKFAQKRWIYED 116
            .::||:|.:| .:||:.||.|:|:|||.||..::..:|.:||.|:...|||.||..:.|:...|:
  Fly    66 VEFDHEAIIGNTKEAQEFDSLSPDESKRRLLILIKMMDLNKDEFIDRHELKAWILRSFKKLSEEE 130

Human   117 VERQWKGHDLNEDGLVSWEEYKNATYGYVLDDPD------PDDGFNYKQMMVR-DERRFKMADKD 174
            ...:::..|.:.|..::|:||...|  |.::|.|      ..|.:..:|.|:: |:..|..||.:
  Fly   131 AADRFEEIDQDADERITWKEYLQDT--YAMEDEDFKKETIDYDSYEDEQKMIKQDKEMFNAADTN 193

Human   175 GDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVK 239
            .|.:.|.|||..|.:|||:..|..|:::.||:|.|.:.||.|:.:|::||..||    .:.||:.
  Fly   194 KDGVLTLEEFVLFQNPEEHPQMLPILLEHTMQDKDADHDGKINFQEFVGDAASH----HDKEWLI 254

Human   240 TEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKDGKLTKEEIVDKYDL 304
            ||:|:|.:..|.|.||.:..:|...||:||:...|..|..||...:|::.|.:|:..||::.||.
  Fly   255 TEKERFDKDHDSNGDGVLTGDEVLSWIVPSNTAIANDEVDHLFVSTDEDHDDRLSYLEILNNYDT 319

Human   305 FVGSQATDFGEAL--VRH--DE 322
            ||||:|||:|:.|  :.|  ||
  Fly   320 FVGSEATDYGDHLQNINHLSDE 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CALU	NP_001186600.1	EFh_CREC_Calumenin	45..307	CDD:320026	94/269 (35%)
		EF-hand motif	45..73	CDD:320026	10/28 (36%)
		EF-hand motif	80..109	CDD:320026	11/28 (39%)
		EF-hand motif	116..145	CDD:320026	6/28 (21%)
		EF-hand motif	163..192	CDD:320026	11/29 (38%)
		EF-hand motif	200..229	CDD:320026	11/28 (39%)
		EF-hand motif	241..270	CDD:320026	11/28 (39%)
		EF-hand motif	277..306	CDD:320026	10/28 (36%)
CG31650	NP_001162879.1	EF-hand_7	100..153	CDD:290234	16/52 (31%)
		EFh	100..153	CDD:298682	16/52 (31%)
		EF-hand_7	184..241	CDD:290234	22/56 (39%)
		EFh	184..241	CDD:298682	22/56 (39%)
		EFh	228..281	CDD:298682	20/56 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4223
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D372250at33208
OrthoFinder	1	1.000	-	-		FOG0000638
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820