DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP3B2 and AP-1-2beta

DIOPT Version :10

Sequence 1:NP_001265441.1 Gene:AP3B2 / 8120 HGNCID:567 Length:1101 Species:Homo sapiens
Sequence 2:NP_523415.1 Gene:AP-1-2beta / 32987 FlyBaseID:FBgn0010380 Length:921 Species:Drosophila melanogaster


Alignment Length:1131 Identity:282/1131 - (24%)
Similarity:463/1131 - (40%) Gaps:281/1131 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    19 EPEYGHDPASGGIFSSDYKRHDDLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVA 83
            :.:|......|.||        :||..|:.:|...|.||:|:::|.:..||:.|.|||.||..:.
  Fly     3 DSKYFTTTKKGEIF--------ELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQ 59

Human    84 CKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMML 148
            ..|:|:|||||:||:.||:.|.|:|:::::||.:..:|.|.||||.|:|.:..|||..|...:..
  Fly    60 TDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCE 124

Human   149 AIKEAASDMSPYVRKTAAHAIPKLYSLDSDQ-KDQ-LIEVIEKLLADKTTLVAGSVVMAFEEVCP 211
            .:::...|..||||||||..:.|||.:.:.. :|| .::.::.||:|...:|..:.|.|..|:..
  Fly   125 PLRKCLKDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINE 189

Human   212 ER------IDLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAFY 270
            ..      :::......||...|.:..|||||.|:..|..|      ||                
  Fly   190 ASQSGQPLVEMNSVTINKLLTALNECTEWGQVFILDSLANY------SP---------------- 232

Human   271 GSEEDEAKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAPKA 335
             .:|.||:.                         :.....|.|...:||||::..::...|....
  Fly   233 -KDEREAQS-------------------------ICERITPRLAHANAAVVLSAVKVLMKLLEML 271

Human   336 E---------VGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRSTDPTQIK 391
            .         ...:|..||.||.|..|||||.|:|:..:..||..:.:..:|.|:::..||..:|
  Fly   272 SSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPIYVK 336

Human   392 ILKLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCLNGLVQLLS 456
            :.||:::..|||::||..||.|.:.|...:|.|||...::||||||..:....:.|::.|:.|:.
  Fly   337 LEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAERCVSTLLDLIQ 401

Human   457 NRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCEHVPRIAPD 521
            .:...||.|::||||.:.:..|.::..||..|.:..|.:..|.||||::|:||||.|.:.. |.:
  Fly   402 TKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGEYAERIDN-ADE 465

Human   522 VLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLSLAKYD-QNYDIRDRARFTRQL 585
            :|....:.|..|...|:||::....||:|.....|:.|.|:|||||..| .|.|:|||.....:|
  Fly   466 LLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDLRDRGFIYWRL 530

Human   586 IVPSEQGGALSRHAKKLFLAPKP-----APVLESSFKDRDHFQLGSLSHLLNAKATGYQELPDWP 645
            :  |....|    ||::.||.||     ..:||.:..|.....:.||:.:.:...|.:.|     
  Fly   531 L--STDPAA----AKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVE----- 584

Human   646 EEAPDPSVRNVEEEDLSLIETHVGLLGEYTEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESA 710
                                                                             
  Fly   585 ----------------------------------------------------------------- 584

Human   711 DSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGE 775
                                                  |||:        |.||:   :|.|   
  Fly   585 --------------------------------------GRGA--------GVRKS---LPNR--- 597

Human   776 ASSSDEGSDSSSSSSESE-MTSESEEEQLEPASWSRKTPPSSKSAP-ATKEISL----LDLEDFT 834
            |:.|..|::.:.:::.|| |...::|..:..........|:..||| ||..:.|    ||:....
  Fly   598 AAGSAAGAEQAENAAGSEAMVIPNQESLIGDLLSMDINAPAMPSAPAATSNVDLLGGGLDILLGG 662

Human   835 PPSVQPVSPPAIVSTSLAADLEGL---TLTDSTLVPSLLSPVSGVGRQELLHRVAGEGLAVDYTF 896
            ||:  ..:|..  :|||..|:.||   ||:....:|.:          ..|....|:||.:..||
  Fly   663 PPA--EAAPGG--ATSLLGDIFGLGGATLSVGVQIPKV----------TWLPAEKGKGLEIQGTF 713

Human   897 SRQPFSGDPHMVSVHIHFSNSSDTPIKGLHVGTPKLPAGISIQEFPEIESLAPGESATAVMGINF 961
            ||:  :|:   |.:.:..:|.:..|:....:...|...|:......:...|.|.:|....|.:..
  Fly   714 SRR--NGE---VFMDMTLTNKAMQPMTNFAIQLNKNSFGLVPASPMQAAPLPPNQSIEVSMALGT 773

Human   962 CDSTQAA----NFQLCTQTR--QFYVS-------IQPPVGELMAPVFMSENEFKKEQGKLMGMNE 1013
            ....|..    |.|:..:..  .||.:       :....|:|...||:  |.:|    ::...||
  Fly   774 NGPIQRMEPLNNLQVAVKNNIDIFYFACLVHGNVLFAEDGQLDKRVFL--NTWK----EIPAANE 832

Human  1014 ITEKLMLPDTCRSDHIVVQKVTATANLGRVPCGTSDEYRFAGRTLTGGSL------------VLL 1066
            :  :..|.....:...:..|:|           |::.:..|.|.:.|..:            |||
  Fly   833 L--QYTLSGVIGTTDGIASKMT-----------TNNIFTIAKRNVEGQDMLYQSLKLTNNIWVLL 884

Human  1067 TLDARPAG-AAQLTVNSEKMVIGTML 1091
            .|..:|.. .|.|::.|..:.:..::
  Fly   885 ELKLQPGNPEATLSLKSRSVEVANII 910

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP3B2NP_001265441.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 1/10 (10%)
Adaptin_N 34..590 CDD:396262 181/573 (32%)
HEAT repeat 111..139 CDD:293787 11/27 (41%)
HEAT repeat 145..173 CDD:293787 10/27 (37%)
HEAT repeat 182..208 CDD:293787 7/26 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 272..295 3/22 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 685..821 19/137 (14%)
AP3B1_C 822..966 CDD:464319 34/150 (23%)
AP-1-2betaNP_523415.1 Adaptin_N 38..535 CDD:396262 174/547 (32%)
HEAT repeat 51..75 CDD:293787 13/23 (57%)
HEAT repeat 87..114 CDD:293787 10/26 (38%)
HEAT repeat 121..151 CDD:293787 12/29 (41%)
HEAT repeat 160..186 CDD:293787 6/25 (24%)
HEAT repeat 197..229 CDD:293787 10/31 (32%)
HEAT repeat 393..417 CDD:293787 8/23 (35%)
HEAT repeat 429..458 CDD:293787 14/28 (50%)
HEAT repeat 465..495 CDD:293787 8/29 (28%)
HEAT repeat 506..542 CDD:293787 16/41 (39%)
Alpha_adaptinC2 703..799 CDD:197886 21/100 (21%)
B2-adapt-app_C 809..919 CDD:198088 23/121 (19%)

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