Protein Alignment AP3B2 and rb

DIOPT Version :10

• Sequence 1: NP_001265441.1
• Gene: AP3B2 / 8120
• HGNCID: 567
• Length: 1101
• Species: Homo sapiens
• Sequence 2: NP_525071.2
• Gene: rb / 31381
• FlyBaseID: FBgn0003210
• Length: 1160
• Species: Drosophila melanogaster
• Alignment Length: 1181
• Identity: 602/1181 - (50%)
• Similarity: 761/1181 - (64%)
• Gaps: 154/1181 - (13%)

Human    21 EYGHDPASG-GIFSSDYKRHDDLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVAC 84
            |:|.||||| ..|.||.::|||||:|||:|||.|||||||||:.|||||::||||||||||||..
  Fly    26 EFGADPASGAAFFQSDGRKHDDLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVS 90

Human    85 KNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLA 149
            |||||||||||||||||||||||||||||||||.|||||||||||||||||||||.:||||:|||
  Fly    91 KNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLA 155

Human   150 IKEAASDMSPYVRKTAAHAIPKLYSLDSDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPERI 214
            |:::|:|:|||||||||||||||||||:||||:|:.||||||:|:||||.||.||||:||||||:
  Fly   156 IRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIEKLLSDRTTLVVGSAVMAFDEVCPERV 220

Human   215 DLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQ------NESLLEENAEKAFY--- 270
            ||||||||||||.|:||:|||||:||:||||||||||:.|..      |:.|.|....:.||
  Fly   221 DLIHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETPVSERFYDES 285

Human   271 ---------GSEEDE--------AKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSA 318
                     ||.:||        ....|...:...::||.. |.:|.|||||||.||||||||:|
  Fly   286 SHSSSHSDDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPSNS-YHIDVDHRLLLRQTKPLLQSRNA 349

Human   319 AVVMAVAQLYFHLAPKAEVGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIR 383
            :|||||||||.|:|||.||.:|||||:||||||.|||.|||..:|:||.||:.:|||:||||::|
  Fly   350 SVVMAVAQLYHHVAPKNEVQLIAKALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVR 414

Human   384 STDPTQIKILKLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCL 448
            ::|||.||:|||::|||||:..:|..:||||||||.|.|:.|||||||||||||::|..|.:|||
  Fly   415 TSDPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCL 479

Human   449 NGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCE 513
            :|||.||||.||.||||||||||:|||.:.|:|.|||..:|||.|.|.||.|||:|:||||||.|
  Fly   480 SGLVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNE 544

Human   514 HVPRIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLSLAKYDQNYDIRDR 578
            .||.|||||||||||||..|:|:|||||:||..||||||.:||.||.|||.:||:||.|||:|||
  Fly   545 KVPLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARYDPNYDVRDR 609

Human   579 ARFTRQLIVP-SEQGGALSRHAKKLFLAPKPAPVLESSFKDRDHFQLGSLSHLLNAKATGYQELP 642
            |||.||:|.| |.....||:||:::|||.|||||.||.::|.::||||||||.||..|.||:|||
  Fly   610 ARFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELP 674

Human   643 DWPEEAPDPSVRNVEEEDLSLIETHVGLL-----GEYTEVPEWTKCSNREKRKEK----EKPFYS 698
            .:|...||.||||:           .|.:     ||.:........|.||..|||    ||.|.|
  Fly   675 AFPVIPPDSSVRNI-----------AGFMQDKLPGEDSPSGHSKDKSGREGGKEKGAGGEKGFLS 728

Human   699 DSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKR 763
            :|              :.:|.:.|:|.|.||||.|.||||::        |.||..|:.||..|:
  Fly   729 ES--------------DDKSSAYSESGSSSGSGTSDSESDSD--------GSGSSDEEEEEVQKQ 771

Human   764 KTKK--KVPER-----------------------------KGEASSSDEGSDSSSSSSESEMTSE 797
            :..|  .|.||                             .|.:.|.|..:.|.|||.:|...|:
  Fly   772 QPTKVSSVKERLIDAGSNELAATSSPVKATINNNNNARGSSGTSDSEDSSAYSGSSSDDSASGSD 836

Human   798 SEEEQLEPASWSRKTP----------PSSKSAPATKEISLLDLEDFTPPSVQPVSPPAIVSTSLA 852
            :|.::.|..:.:...|          |...:..:..:: ||||:|.  |.:.||..|::
  Fly   837 NEVKKNETKTDTGTKPEKLKEKHEKQPEQTAVKSNLDL-LLDLDDI--PPIGPVMTPSL------ 892

Human   853 ADLEGLTLTDSTLVPSL------LSP------VSGVG-------RQELLHRVAGEGLAVDYTFSR 898
                |..||..|  |.:      |.|      |..||       .:|||::|:|.||.:.|.|:|
  Fly   893 ----GGFLTPGT--PMMAGQAAPLQPQHARNRVELVGPSHIEFKHKELLNKVSGHGLHLAYRFTR 951

Human   899 QPFSGDPHMVSVHIHFSNSSDTPIKGLHVGTPKLPAGISIQEFPEIESLAPGESATAVMGINFCD 963
            .|......|.|:.:.|.|..:..|..:.:|...||||:.:.||..|..|.|.::|:.|:|::|.|
  Fly   952 SPHLYSSSMCSIELQFQNRGEKEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASGVLGVDFND 1016

Human   964 STQAANFQLCTQTRQFYVSIQPPVGELMAPVFMSENEFKKEQGKLMGMNEITEKLMLPDTCRSDH 1028
            ||.|.:.:|.:......:.::||||||:..|.:.|:..::|:.||.||||...:|.   ..|.|.
  Fly  1017 STHAVDLELLSSAGSSRLQLKPPVGELVRSVQIGESCHREERAKLRGMNEHQCELR---GLRQDL 1078

Human  1029 IVV----QKVTATANLGRVPCGTSDE-YRFAGRTLTGGSLVLLTLDARPAGAAQLTVNSEKMVIG 1088
            |.|    |||..:.|:......:|.: :.|||:||:..||||||||.:...|..|.||.||||||
  Fly  1079 IDVVALRQKVFESINVAHTHSSSSGQLHCFAGQTLSSKSLVLLTLDWKTEDALTLLVNCEKMVIG 1143

Human  1089 TMLVKDVIQAL 1099
            :|::.::..||
  Fly  1144 SMVLNELRNAL 1154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP3B2	NP_001265441.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		7/9 (78%)
		Adaptin_N	34..590	CDD:396262	399/582 (69%)
		HEAT repeat	111..139	CDD:293787	26/27 (96%)
		HEAT repeat	145..173	CDD:293787	21/27 (78%)
		HEAT repeat	182..208	CDD:293787	18/25 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	272..295		6/30 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	685..821		47/180 (26%)
		AP3B1_C	822..966	CDD:464319	51/162 (31%)
rb	NP_525071.2	Adaptin_N	40..621	CDD:396262	399/581 (69%)
		HEAT repeat	48..73	CDD:293787	19/24 (79%)
		HEAT repeat	117..144	CDD:293787	25/26 (96%)
		HEAT repeat	147..179	CDD:293787	24/31 (77%)
		HEAT repeat	188..214	CDD:293787	18/25 (72%)
		AP3B1_C	881..1019	CDD:464319	46/151 (30%)