DRSC/TRiP Functional Genomics Resources

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Protein Alignment CALR and Calr

DIOPT Version :10

Sequence 1:NP_004334.1 Gene:CALR / 811 HGNCID:1455 Length:417 Species:Homo sapiens
Sequence 2:NP_524293.2 Gene:Calr / 41166 FlyBaseID:FBgn0005585 Length:406 Species:Drosophila melanogaster


Alignment Length:407 Identity:272/407 - (66%)
Similarity:321/407 - (78%) Gaps:7/407 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     4 SVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHK-SDFGKFVLSSGKFYGDEEKDKGLQ 67
            :|.:||..:|...||  ||.||.| |.:.|...||.|||. .:||||||:.|.||.|.|.|||:|
  Fly     6 TVIVLLATVGFISAE--VYLKENF-DNENWEDTWIYSKHPGKEFGKFVLTPGTFYNDAEADKGIQ 67

Human    68 TSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDMHGDSEYNIMF 132
            |||||||||.|..|:.|||:.:.|||||:|||||||||||||||||..|||||||||:|.|.|||
  Fly    68 TSQDARFYAASRKFDGFSNEDKPLVVQFSVKHEQNIDCGGGYVKLFDCSLDQTDMHGESPYEIMF 132

Human   133 GPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLE 197
            ||||||||||||||||:|||||.||:||||||||.:||.|||||||||||||.|||.:||||:||
  Fly   133 GPDICGPGTKKVHVIFSYKGKNHLISKDIRCKDDVYTHFYTLIVRPDNTYEVLIDNEKVESGNLE 197

Human   198 DDWDFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWE 262
            ||||||.|||||||.|:||||||:||.|.||.|.||||||||||||||||.||||||:|||||||
  Fly   198 DDWDFLAPKKIKDPTATKPEDWDDRATIPDPDDKKPEDWDKPEHIPDPDATKPEDWDDEMDGEWE 262

Human   263 PPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYSPDPSIYAYDNFGVLGLDLWQVKSGTIF 327
            ||:|.|||:||||:|:|:|||:|||.|.||||.||||.||..:|.......||.|||||||||||
  Fly   263 PPMIDNPEFKGEWQPKQLDNPNYKGAWEHPEIANPEYVPDDKLYLRKEICTLGFDLWQVKSGTIF 327

Human   328 DNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDEDKD 392
            ||.|||:|...|.:...|... |:|.||:||:.|||.||.|:|||.||..:::: || |||:|::
  Fly   328 DNVLITDDVELAAKAAAEVKN-TQAGEKKMKEAQDEVQRKKDEEEAKKASDKDD-ED-EDDDDEE 389

Human   393 EDEEDEEDKEEDEEEDV 409
            :|:|.::||::.|.:::
  Fly   390 KDDESKQDKDQSEHDEL 406

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CALRNP_004334.1 N-domain 18..197 131/179 (73%)
Calreticulin 23..332 CDD:459737 230/309 (74%)
4 X approximate repeats 191..255 53/63 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 193..278 69/84 (82%)
P-domain 198..308 85/109 (78%)
Interaction with PPIB. /evidence=ECO:0000250 237..270 28/32 (88%)
3 X approximate repeats 259..297 27/37 (73%)
C-domain 309..417 49/101 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..417 28/60 (47%)
Prevents secretion from ER 414..417
CalrNP_524293.2 Calreticulin 25..332 CDD:459737 229/307 (75%)
Blue background indicates that the domain is not in the aligned region.

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