Protein Alignment PABPN1 and Pabpn1

DIOPT Version :10

• Sequence 1: NP_004634.1
• Gene: PABPN1 / 8106
• HGNCID: 8565
• Length: 306
• Species: Homo sapiens
• Sequence 2: NP_062275.1
• Gene: Pabpn1 / 54196
• MGIID: 1859158
• Length: 302
• Species: Mus musculus
• Alignment Length: 306
• Identity: 296/306 - (96%)
• Similarity: 299/306 - (97%)
• Gaps: 4/306 - (1%)

Human     1 MAAAAAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGAPGGAGDYGNGLESEELEPEELLLEPE 65
            ||||||||||||||||||||||||||||||||||||||.||||||||||||||||||.|||
Mouse     1 MAAAAAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGDPGGAGDYGNGLESEELEPGELL---- 61

Human    66 PEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVEGDPGDGAIEDPELEAIKARVREME 130
            |||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||
Mouse    62 PEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVEADPGDGAIEDPELEAIKARVREME 126

Human   131 EEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSIEEKMEADARSIYVGNVDYGATAEELEAHFHGC 195
            ||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||
Mouse   127 EEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSLEEKMEADARSIYVGNVDYGATAEELEAHFHGC 191

Human   196 GSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRG 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   192 GSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRG 256

Human   261 FPRARYRARTTNYNSSRSRFYSGFNSRPRGRVYRGRARATSWYSPY 306
            |||:|||||||||||||||||||||||||||:||||||||||||||
Mouse   257 FPRSRYRARTTNYNSSRSRFYSGFNSRPRGRIYRGRARATSWYSPY 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PABPN1	NP_004634.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..115		106/113 (94%)
		Interaction with SKIP. /evidence=ECO:0000269|PubMed:11371506	2..145		135/142 (95%)
		GCG-encoded polyalanine repeat	2..7		4/4 (100%)
		Stimulates PAPOLA. /evidence=ECO:0000250	119..147		27/27 (100%)
		Necessary for homooligomerization	155..306		147/150 (98%)
		RRM_II_PABPN1	173..248	CDD:409966	74/74 (100%)
		Interaction with PAPOLA. /evidence=ECO:0000250	286..306		18/19 (95%)
Pabpn1	NP_062275.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..111		106/113 (94%)
		Interaction with SKIP. /evidence=ECO:0000250	2..141		135/142 (95%)
		Stimulates PAPOLA. /evidence=ECO:0000250	115..143		27/27 (100%)
		RRM_II_PABPN1	169..244	CDD:409966	74/74 (100%)
		Strong poly(A) affinity and self-association. /evidence=ECO:0000250	255..302		44/46 (96%)
		Interaction with PAPOLA. /evidence=ECO:0000250	282..302		18/19 (95%)