Protein Alignment PABPN1 and eIF4H2

DIOPT Version :10

• Sequence 1: NP_004634.1
• Gene: PABPN1 / 8106
• HGNCID: 8565
• Length: 306
• Species: Homo sapiens
• Sequence 2: NP_651820.1
• Gene: eIF4H2 / 43645
• FlyBaseID: FBgn0039797
• Length: 459
• Species: Drosophila melanogaster
• Alignment Length: 251
• Identity: 45/251 - (17%)
• Similarity: 73/251 - (29%)
• Gaps: 105/251 - (41%)

Human   127 REMEEEAEKLKELQN--------EVEKQMNMSPPPGNAGPVIMSIEEKMEADARSIYVGNVDYGA 183
            |:..:..|.....||        :.::|:...||                   ...||||:..|.
  Fly    29 RDNRDNRENRSNFQNYRNRDRDRDRQRQVPTEPP-------------------FIAYVGNLPKGL 74

Human   184 TAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGR-------- 240
            ...::...|... .|..|.::.|:.:...||:.|:||.....::::|..:     ||
  Fly    75 VQGDVMKIFSDF-EVKNVRLIKDRETDEFKGYGYVEFETLAQLKSALNCN-----GRIKLDNFSA 133

Human   241 --QIKVIPKRTNRPGISTTDRGFPRA--------------------------------------- 264
              :|.:...|...||..:...|.|.|
  Fly   134 PLRIDIADHRRQNPGAPSGVGGAPPAGVGHERGGGVGRGGSTGAANGNNPYYQRRNYRRDDSVGS 198

Human   265 -RYRARTTNYNSSRSRFYS------------------GFNSR----PRGRVYRGRA 297
             ::|.|....|||..:..:                  |||||    ..|..|:|.|
  Fly   199 HQFRRREPRSNSSNHQMSNSSPTQSTTSINYNRTTRGGFNSRVAVGGNGNRYQGGA 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PABPN1	NP_004634.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..115
		Interaction with SKIP. /evidence=ECO:0000269|PubMed:11371506	2..145		4/25 (16%)
		GCG-encoded polyalanine repeat	2..7
		Stimulates PAPOLA. /evidence=ECO:0000250	119..147		4/27 (15%)
		Necessary for homooligomerization	155..306		38/215 (18%)
		RRM_II_PABPN1	173..248	CDD:409966	18/84 (21%)
		Interaction with PAPOLA. /evidence=ECO:0000250	286..306		6/16 (38%)
eIF4H2	NP_651820.1	RRM_SF	58..144	CDD:473069	20/110 (18%)