Protein Alignment PABPN1 and Rb97D

DIOPT Version :10

• Sequence 1: NP_004634.1
• Gene: PABPN1 / 8106
• HGNCID: 8565
• Length: 306
• Species: Homo sapiens
• Sequence 2: NP_524520.1
• Gene: Rb97D / 43231
• FlyBaseID: FBgn0004903
• Length: 471
• Species: Drosophila melanogaster
• Alignment Length: 169
• Identity: 35/169 - (20%)
• Similarity: 64/169 - (37%)
• Gaps: 60/169 - (35%)

Human    98 EEEEPGLVEGDPGDGAIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMS 162
            :|..|.:::|         ..:||.:|..|...|            .::.|:|
  Fly    90 QENRPHIIDG---------KTVEAKRALPRPERE------------SRETNIS------------ 121

Human   163 IEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVR 227
                    .:.::||.:......|.|..:|...|:|..|.:|.||.:|..:|||::||.|.:
  Fly   122 --------VKKLFVGGLKDNHDEECLREYFLQFGNVVSVKLLTDKTTGKRRGFAFVEFDDYD--- 175

Human   228 TSLALDESLFRGRQ-IKVI------------PKRTNRPG 253
               |:|:::.:.:. ||.:            .|...:||
  Fly   176 ---AVDKAILKKQHAIKYVHVDVKKSIYNLDKKEKQQPG 211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PABPN1	NP_004634.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..115		3/16 (19%)
		Interaction with SKIP. /evidence=ECO:0000269|PubMed:11371506	2..145		8/46 (17%)
		GCG-encoded polyalanine repeat	2..7
		Stimulates PAPOLA. /evidence=ECO:0000250	119..147		5/27 (19%)
		Necessary for homooligomerization	155..306		25/112 (22%)
		RRM_II_PABPN1	173..248	CDD:409966	22/87 (25%)
		Interaction with PAPOLA. /evidence=ECO:0000250	286..306
Rb97D	NP_524520.1	RRM2_hnRNPA_like	124..196	CDD:409766	22/77 (29%)
		RRM_SF	33..110	CDD:473069	6/28 (21%)