DRSC/TRiP Functional Genomics Resources

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Protein Alignment PABPN1 and RnpS1

DIOPT Version :9

Sequence 1:NP_004634.1 Gene:PABPN1 / 8106 HGNCID:8565 Length:306 Species:Homo sapiens
Sequence 2:NP_649903.1 Gene:RnpS1 / 41147 FlyBaseID:FBgn0037707 Length:374 Species:Drosophila melanogaster


Alignment Length:301 Identity:64/301 - (21%)
Similarity:111/301 - (36%) Gaps:59/301 - (19%)


- Green bases have known domain annotations that are detailed below.


Human     5 AAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGAPGGAGDYGNGLESEELEPEELLLEPEPEPE 69
            :::::::.::....|...|||     .||.||:..........:...|....|..:...|.|..:
  Fly    79 SSSSSSSSSSDSDRSEKNRRR-----GGGAAGKDKDKDKPSARSRSRSRTRSPRRVSKSPRPGSK 138

Human    70 PEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVEGDPGDGAIEDPELEAIKARVREMEEEAE 134
            ..:||.|.|           .....|::.....|     ..|.|..|.  ..:|   ||....|.
  Fly   139 ARKEPERDR-----------DRRSRSRDRARRAG-----SNDRAAADS--NNVK---RERSRSAS 182

Human   135 KLKELQNEVEKQMNMSPPPGNAGPVIMSIEEKMEADARS-------IYVGNVDYGATAEELEAHF 192
            :.:..:......:..:|||..        .|:..:..||       |:||.:....|.:.:...|
  Fly   183 RSRSPRRRGRGSVERTPPPKR--------RERSRSRTRSPSPKQVRIHVGRLTRNVTKDHVFEIF 239

Human   193 HGCGSVNRVTILCDKFSGHP---KGFAYIEFSDKESVRTSLA-LDESLFRGRQIKVIP----KRT 249
            ...|.|..|....|:|  ||   :|.|::|::..|...:::. :|.....|::|.|.|    |: 
  Fly   240 SSFGDVKNVEFPVDRF--HPNFGRGVAFVEYATPEDCESAMKHMDGGQIDGQEITVSPVVLVKQ- 301

Human   250 NRPGISTTDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRG 290
             ||.:.   |..|..| |.:...:.|...  ::.||:|..|
  Fly   302 -RPPMR---RPSPPMR-RPQNNRWRSPPQ--FNRFNNRGGG 335

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PABPN1NP_004634.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..115 20/109 (18%)
Interaction with SKIP. /evidence=ECO:0000269|PubMed:11371506 2..145 25/139 (18%)
GCG-encoded polyalanine repeat 2..7 0/1 (0%)
RRM 113..>289 CDD:223796 44/190 (23%)
Stimulates PAPOLA. /evidence=ECO:0000250 119..147 4/27 (15%)
Necessary for homooligomerization 155..306 36/151 (24%)
RRM_II_PABPN1 173..248 CDD:409966 22/89 (25%)
Interaction with PAPOLA. /evidence=ECO:0000250 286..306 2/5 (40%)
RnpS1NP_649903.1 RRM <196..>301 CDD:223796 27/114 (24%)
RRM_RNPS1 221..294 CDD:240811 19/74 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4209
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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