Protein Alignment PABPN1 and CG11726

DIOPT Version :10

• Sequence 1: NP_004634.1
• Gene: PABPN1 / 8106
• HGNCID: 8565
• Length: 306
• Species: Homo sapiens
• Sequence 2: NP_648461.1
• Gene: CG11726 / 39275
• FlyBaseID: FBgn0036156
• Length: 291
• Species: Drosophila melanogaster
• Alignment Length: 183
• Identity: 47/183 - (25%)
• Similarity: 75/183 - (40%)
• Gaps: 30/183 - (16%)

Human   105 VEGDPGDGAIEDPELEAIKARVREMEEEAEKL------KELQNEVEKQMNMSPPPGNAGPVIMSI 163
            |.|......:|| .|...|.|..:: :.||..      |:..::::|::: :|.|
  Fly    24 VSGSESGQGLED-MLHVTKVRTSQV-DNAELFMYGDGPKKSNSDLQKKVS-TPDP---------- 75

Human   164 EEKMEADARSI-YVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVR 227
            ||::..:...: .|.|:....|..||...|... |:..:||  .|....||||||:|...:|.:.
  Fly    76 EEEVSMEPPFVALVSNLPMECTEGELRKVFTSF-SIRSLTI--PKKGKRPKGFAYVEMDSREDLV 137

Human   228 TSLALDESLFRGR----QIKVIPKRTNRPGISTTDRGFPRARYRARTTNYNSS 276
            ..|.:|:...|||    :|..:|.   .|.......||.......|..:.|||
  Fly   138 RLLKMDKLKCRGRCLMAKIGQLPP---EPPTKAAGDGFSLFTCSGRQFDINSS 187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PABPN1	NP_004634.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..115		2/9 (22%)
		Interaction with SKIP. /evidence=ECO:0000269|PubMed:11371506	2..145		10/45 (22%)
		GCG-encoded polyalanine repeat	2..7
		Stimulates PAPOLA. /evidence=ECO:0000250	119..147		7/33 (21%)
		Necessary for homooligomerization	155..306		34/127 (27%)
		RRM_II_PABPN1	173..248	CDD:409966	25/79 (32%)
		Interaction with PAPOLA. /evidence=ECO:0000250	286..306
CG11726	NP_648461.1	RRM_SF	83..150	CDD:473069	21/69 (30%)