Protein Alignment PABPN1 and lark

DIOPT Version :10

• Sequence 1: NP_004634.1
• Gene: PABPN1 / 8106
• HGNCID: 8565
• Length: 306
• Species: Homo sapiens
• Sequence 2: NP_523957.1
• Gene: lark / 38811
• FlyBaseID: FBgn0011640
• Length: 352
• Species: Drosophila melanogaster
• Alignment Length: 199
• Identity: 46/199 - (23%)
• Similarity: 79/199 - (39%)
• Gaps: 50/199 - (25%)

Human   129 MEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSIEEKMEADARS----------IYVGNVDYGA 183
            ||.|.:....:||     :|        |..:.....|:|| |:|          |:|||:....
  Fly    47 METEQQGRDAIQN-----LN--------GYTLNEFAIKVEA-AKSRRAPNTPTTKIFVGNLTDKT 97

Human   184 TAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIE-FSD-KESVRTSLALDESLFRGRQIKVIP 246
            .|.|:...|...|:|    :.||....:  ||.::: ..| :::::   .|:..:..|:.:||..
  Fly    98 RAPEVRELFQKYGTV----VECDIVRNY--GFVHLDCVGDVQDAIK---ELNGRVVDGQPLKVQV 153

Human   247 KRTN---RPGISTTDRGFPRARYR-ARTTNYNSSRSRFY--SGFNSRPRGRV----YRGRARATS 301
            ..:.   :||:     |.|...|| .|:.:::....|.|  :|....|...:    ||.|.....
  Fly   154 STSRVRPKPGM-----GDPEQCYRCGRSGHWSKECPRLYGSAGGGREPPSPLSAGGYRDRMYGRD 213

Human   302 WYSP 305
            .|.|
  Fly   214 PYPP 217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PABPN1	NP_004634.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..115
		Interaction with SKIP. /evidence=ECO:0000269|PubMed:11371506	2..145		5/15 (33%)
		GCG-encoded polyalanine repeat	2..7
		Stimulates PAPOLA. /evidence=ECO:0000250	119..147		5/17 (29%)
		Necessary for homooligomerization	155..306		40/173 (23%)
		RRM_II_PABPN1	173..248	CDD:409966	19/86 (22%)
		Interaction with PAPOLA. /evidence=ECO:0000250	286..306		6/24 (25%)
lark	NP_523957.1	RRM1_2_CoAA_like	8..73	CDD:409779	8/38 (21%)
		RRM1_2_CoAA_like	87..152	CDD:409779	17/73 (23%)
		hnRNP-R-Q	<88..>258	CDD:273732	34/144 (24%)