Protein Alignment PABPN1 and CG3594

DIOPT Version :10

• Sequence 1: NP_004634.1
• Gene: PABPN1 / 8106
• HGNCID: 8565
• Length: 306
• Species: Homo sapiens
• Sequence 2: NP_523855.1
• Gene: CG3594 / 37964
• FlyBaseID: FBgn0035063
• Length: 250
• Species: Drosophila melanogaster
• Alignment Length: 242
• Identity: 51/242 - (21%)
• Similarity: 81/242 - (33%)
• Gaps: 72/242 - (29%)

Human    69 EPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEE-EPGLVEGDPGDGAIEDPELEAIKARVREMEEE 132
            :||:......|.........||.|.|::|||. |.|.:..|
  Fly    59 DPEDSKSEDEAKSDDEAAAEGSAASGAEEEESAENGQITSD------------------------ 99

Human   133 AEKLKELQNEVEKQMNMSPPPGNAGPVIMSIEEKMEADARSIYVGNVDYGATAEELEAHFHGCGS 197
              :|..|.....|                       .:...:||.|:::..|.::||.||...|:
  Fly   100 --QLSSLLRGASK-----------------------TNRHVLYVTNLNFETTKDDLELHFSAAGT 139

Human   198 VNRVTILCDKFSGHPK----GFAYIEFSDKESVRTSLALDESLFRGRQIKV------IPKRTNRP 252
            |..:.|        ||    |||::|.:|..|.:.:..|..:..:||.|||      ..|..|:.
  Fly   140 VKSIRI--------PKKRRGGFAFVEMADLSSFQNAFQLHNTELQGRNIKVQISEAGKKKSANKK 196

Human   253 G-ISTTDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGRVYRGRAR 298
            . |...:|.....|...:|.   :...:||.....:.:.:....|.|
  Fly   197 NIIKQKNRKLAEMRNEQKTF---TKSGKFYDKDLKKEKAKEMLARKR 240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PABPN1	NP_004634.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..115		13/46 (28%)
		Interaction with SKIP. /evidence=ECO:0000269|PubMed:11371506	2..145		15/76 (20%)
		GCG-encoded polyalanine repeat	2..7
		Stimulates PAPOLA. /evidence=ECO:0000250	119..147		3/27 (11%)
		Necessary for homooligomerization	155..306		35/155 (23%)
		RRM_II_PABPN1	173..248	CDD:409966	25/84 (30%)
		Interaction with PAPOLA. /evidence=ECO:0000250	286..306		2/13 (15%)
CG3594	NP_523855.1	SF-CC1	36..>197	CDD:273721	43/194 (22%)
		RRM	116..187	CDD:440488	25/78 (32%)