Protein Alignment PABPN1 and CG11454

DIOPT Version :10

• Sequence 1: NP_004634.1
• Gene: PABPN1 / 8106
• HGNCID: 8565
• Length: 306
• Species: Homo sapiens
• Sequence 2: NP_608497.1
• Gene: CG11454 / 33175
• FlyBaseID: FBgn0031224
• Length: 238
• Species: Drosophila melanogaster
• Alignment Length: 135
• Identity: 32/135 - (23%)
• Similarity: 55/135 - (40%)
• Gaps: 28/135 - (20%)

Human   152 PPGNAGPVIMSIE----EKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHP 212
            |..|...::..:|    |:.:.:.|:::.||:|...|.|.|...|...|.:..|.|..|. :|.|
  Fly    46 PNENGDQLVGQLEDDDDEEEDEEQRTLFCGNLDERVTEEILYEVFLQAGPIEGVRIPTDN-NGRP 109

Human   213 KGFAYIEFSDKESVRTSLALDESLFRGRQI---KVIPKRTNRPGISTTDRGFPRARYRARTTNYN 274
            :.|.::.:  :.......|||  |::|.::   ||..|:.....:..                ||
  Fly   110 RNFGFVTY--QRLCAVPFALD--LYQGLELFQKKVTIKQQGGKQLPA----------------YN 154

Human   275 SSRSR 279
            .||.|
  Fly   155 QSRLR 159

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PABPN1	NP_004634.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..115
		Interaction with SKIP. /evidence=ECO:0000269|PubMed:11371506	2..145
		GCG-encoded polyalanine repeat	2..7
		Stimulates PAPOLA. /evidence=ECO:0000250	119..147
		Necessary for homooligomerization	155..306		31/132 (23%)
		RRM_II_PABPN1	173..248	CDD:409966	21/77 (27%)
		Interaction with PAPOLA. /evidence=ECO:0000250	286..306
CG11454	NP_608497.1	RRM_RBM7_like	69..143	CDD:409773	22/78 (28%)