DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACTN4 and Dys

DIOPT Version :9

Sequence 1:XP_016882820.1 Gene:ACTN4 / 81 HGNCID:166 Length:933 Species:Homo sapiens
Sequence 2:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster


Alignment Length:929 Identity:213/929 - (22%)
Similarity:372/929 - (40%) Gaps:243/929 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    42 LLLDPAWEKQ--QRKTFTAWCNSHLRKAG-TQIENIDEDFRDGLKLMLLLEVISGERLPKPERGK 103
            :|:|   |:|  |:||||.|.||||.... |.::::..|.|||.:|:.||..::...| |||:|:
  Fly     5 ILID---ERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGR 65

Human   104 MRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDI--SVEETSAK 166
            ||||.|||:||.:..|...|||||:|.:::||.||||:|||:||.|.|.|..|.:  |......:
  Fly    66 MRVHHINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVE 130

Human   167 EGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPEL-----IEYDKLRKDDPVTNLNN 226
            :.||.|.::.|.|: .:.:.:|..||.||.||..::..|..||     ::...|::      |:.
  Fly   131 KSLLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQHALKR------LHL 188

Human   227 AFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAE---------------- 275
            ||::|.::..|.|:||||| |:|.:||.|:|..||...|||....:..:                
  Fly   189 AFDLAHRHFKIEKLLDAED-VHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRV 252

Human   276 --TAANRICKVLAVNQENE----------------------HLM-------------EDYEKLAS 303
              |:...:.:|...|.:..                      |.|             ..|:....
  Fly   253 PCTSITDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALE 317

Human   304 DLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSN 368
            .:|..:      |||.      |.:.|.|.|.:|::..        |.|...|.:.:   |:|:.
  Fly   318 AVLTLL------LEDE------QLLSQNLPDPQDFQTA--------KLQFHENESFM---LKLTE 359

Human   369 RPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIR-------------RLERLD-------H 413
            ...::   |:.:.:.:|.....::|..|..:...||:|             ||..||       .
  Fly   360 HQEYV---GEALEEGSNLINESQKAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMR 421

Human   414 LAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQ 478
            |||..:||......:....|..:.|......||.:.:..:.:.:..::||:..|:.|:.::::..
  Fly   422 LAEFQKQKLEQLRQFLTSVEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVV 486

Human   479 ELNELDYYDSHNVN---TRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF 540
            .:|:    .|.|.|   .|...:.::|..:...:..|:|.|:    |.:.|              
  Fly   487 IVND----TSGNFNDLEDRLSALGERWSHVVKWSDLRKEKLQ----QYKCI-------------- 529

Human   541 NNWMESAMEDLQDM---------FIVHTIEEI-----------EGLISAHDQFKSTLPDADRERE 585
            :.|:::..:||:.|         .|...|.|:           ..||.......:||.|.|.:.|
  Fly   530 SRWLDAREQDLKLMESRDVTDVGGITQRINELNYCAKDLLELQRYLIDLRQMVAATLQDGDDKGE 594

Human   586 AILAIHKEA--------QRIAESNHIKLS------GSNPYTTVTPQIINSK-WEKVQQLVPKRDH 635
            .:| |..|:        ::|.|...:::.      |.:..:....:::..: |...|.::     
  Fly   595 RVL-IQLESYEDRLDALKQIVEVQTVRIETKGFNFGRDRASYDDSRVVRPEGWVDYQMII----- 653

Human   636 ALLEEQSKQQSNEH--------LRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQ 692
            ...|:.|::..:||        ||.  |...|.:...|   ||..|.:.     .:|.:|..|::
  Fly   654 RFGEDDSQEDDDEHDLASKKRKLRN--ADNFNALENHI---MEHFGYVQ-----EVEQKLQQLQR 708

Human   693 YERSIVDYKPNLDLLEQQHQLIQ--------------------EALIFDNKHTNYTME--HIRVG 735
            ..            |.||.:|::                    |....::...|..:|  ||: .
  Fly   709 QS------------LRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLEETHIK-Q 760

Human   736 WEQLLTTIARTINEVENQILTRDAKGISQEQMQEFR---ASFNHFDKDHGGALGPEEFKACLISL 797
            .||....:::.::..:::..|..||......:..|:   |....:.|.|.|:....|.:..|..:
  Fly   761 LEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRDWYKQHAGSASGNELEQRLSHM 825

Human   798 GYDVENDRQKQTGSMDSDD 816
            ........:.:|.:.:.||
  Fly   826 ESLASEISEAKTATEELDD 844

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACTN4XP_016882820.1 CH_ACTN_rpt1 47..151 CDD:409063 53/106 (50%)
CH_ACTN_rpt2 155..269 CDD:409065 40/120 (33%)
SPEC 296..517 CDD:238103 47/243 (19%)
SPEC 414..640 CDD:238103 46/263 (17%)
SPEC 532..754 CDD:238103 48/286 (17%)
PTZ00184 759..>890 CDD:185504 12/61 (20%)
EFhand_Ca_insen 863..929 CDD:400872
DysNP_001036722.1 CH 13..111 CDD:278723 50/98 (51%)
CH 129..225 CDD:278723 35/103 (34%)
SPEC 312..525 CDD:238103 48/246 (20%)
SbcC <325..957 CDD:223496 108/591 (18%)
Smc <816..1591 CDD:224117 5/29 (17%)
SPEC 1174..1365 CDD:238103
SPEC 1289..1485 CDD:295325
SPEC 2369..2576 CDD:238103
SPEC 2477..2714 CDD:238103
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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