Protein Alignment ACTN4 and MICAL-like

DIOPT Version :10

• Sequence 1: NP_001427225.1
• Gene: ACTN4 / 81
• HGNCID: 166
• Length: 933
• Species: Homo sapiens
• Sequence 2: NP_648621.1
• Gene: MICAL-like / 39475
• FlyBaseID: FBgn0036333
• Length: 1010
• Species: Drosophila melanogaster
• Alignment Length: 977
• Identity: 196/977 - (20%)
• Similarity: 324/977 - (33%)
• Gaps: 360/977 - (36%)

Human   167 EGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVA 231
            :.|..||:..|..|..|.|:|...||::||||.|:||..||:||::|:|:.||...|.:.||..|
  Fly    14 KALEYWCRVVTQGYNGVKVENMTTSWRNGLAFCAIIHHFRPDLIDFDRLKADDIYENNDLAFTTA 78

Human   232 EKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQK----------------------- 273
            ||||.||.:|||.|:|:...||..:|:||:|.||.....:.|
  Fly    79 EKYLGIPALLDAADMVSYEVPDRLSILTYLSQFYKVLGKSLKHPKPEEPLGEESEPPQKVMHIVG 143

Human   274 ----------------------------------------------AETAANRI-CKVLAVNQEN 291
                                                          .||..|.| |.....::|:
  Fly   144 MPRRDKCQKCNLPVFLAERVLVGKRAYHRTCLKCARCSSLLTPGSFYETEVNNIYCCETCPDEES 208

Human   292 EHLMEDYEKLASDLLEWIRRTIPWLEDR--VPQKT----IQEMQQKLEDFRDYRRVHK-----PP 345
            |.        .||:|:....|.....|:  |.|.:    .::.|:.||| .|.|...|     ||
  Fly   209 EP--------ESDILKLKTTTTDSPNDKQMVAQSSDYSEAEDKQEDLED-NDIRTTDKPENFQPP 264

Human   346 KVQEKCQLEINFNTLQTKLRLSNRPAFMP---SEGKMVSDINNGWQHLEQA--EK---------- 395
            ..:::...|:..|.:...|....:.:|:|   .:|.::...|.....::.|  ||
  Fly   265 SNKDEQNNELTINPVNPILSEERKISFIPLDEEDGGLIEQYNKSTTPVKPAIPEKPKVSTLPLDD 329

Human   396 ----GYEEWLLNEIRRLERLDHLAEKFRQKA-------------SIHEAWTDGKEAM-------- 435
                |.|:  .|::......|...||.:..:             :||....|.:||:
  Fly   330 EQHAGVEQ--NNDLAVSPENDIPKEKLKISSVSIYLEDDRLVVDAIHPDNLDKQEALNNTSDALI 392

Human   436 ----------------LKHRDY-----ETATLSDIKALIRKHEAF--ESDLAAHQDRVEQIAAIA 477
                            :|..|:     |....|:.::..::....  :.||.:.:|:|     |.
  Fly   393 PESQEAPIPENNTQVAIKPEDHISPRKENKIFSNTESCSKQEGVLPKQMDLESPKDKV-----IE 452

Human   478 QELNELDY------------------YDSHNVNTRCQKICDQWDALG------------------ 506
            .:.:|.||                  :||.:......|......:.|
  Fly   453 TKASETDYPEDLNPFKDDDSSKGANPFDSSDDEVELLKAIPAQQSKGKVVPPRPPPPKIGLSSIS 517

Human   507 ----------SLTHSR-------REALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDM 554
                      :|:|.:       |.::.||  |..|....|      ....::...|:.|.|..
  Fly   518 NPSEKPHSSPTLSHGKKMPMPTPRISISKT--QTPAKPMTH------QGQKSSISSSSSEHLNS- 573

Human   555 FIVHTIEEIEGLISAHDQFKS-TLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQI 618
              :.|.:.     .|.|:..| :||.|:..|:.:        |.:..:.::...|:|.|:::.
  Fly   574 --IRTFDR-----GADDRGSSISLPSANGPRKPL--------RASVGSPLRSEESSPTTSLSS-- 621

Human   619 INSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEE---IGRISIEMN 680
            |.|...|      ||...|                         |.|||..:.   ..::|.|..
  Fly   622 ITSPMRK------KRQAPL-------------------------PPIQTDFDSDPGFSKLSDEQK 655

Human   681 GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLI--QEALIFD--NKHTNY--------TMEHIR 733
            ..|..||.            .|||.  :...:||  .::|:.|  .:.:||        ..|.:.
  Fly   656 ALLHTQLK------------APNLG--DSTRRLIPLDQSLLSDEATESSNYDESLSTSNADEEVN 706

Human   734 VGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLG 798
            |.:.::|....:..|.||.          |:|. |:....:|.||::    :.|         ||
  Fly   707 VVYRRILVPPTQPENTVER----------SKED-QKSPIVYNDFDRN----VSP---------LG 747

Human   799 YDVEN----DRQKQTGSMDSDDFRALLISTGYSLGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSR 859
            ::...    .|:|..........|.:|    ..|...|......::.....||......::.|.|
  Fly   748 HNKSTHGKWKRRKGPAPAVPIPPRKVL----QRLPLQEIRHEFEIIAVQQLGLEKQGVILEKMIR 808

Human   860 -------ETTDTD-------------TADQVIASFKVLAGDKNFITAEE-----LRRE--LPPDQ 897
                   :.||||             ..|.::..|: |..:||.:...:     |||:  |..:|
  Fly   809 DRCERSLDATDTDGPESAEVLTNSKEVEDLILQLFE-LVNEKNELFRRQAELMYLRRQHRLEQEQ 872

Human   898 AE 899
            |:
  Fly   873 AD 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACTN4	NP_001427225.1	None
MICAL-like	NP_648621.1	CH_MICALL2	11..115	CDD:409102	48/100 (48%)
		LIM_like_1	146..207	CDD:188784	5/60 (8%)
		PTZ00449	<411..727	CDD:185628	68/401 (17%)
		bMERB_dom	785..933	CDD:463467	19/91 (21%)