DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACTN4 and Ehbp1

DIOPT Version :9

Sequence 1:	XP_016882820.1	Gene:	ACTN4 / 81	HGNCID:	166	Length:	933	Species:	Homo sapiens
Sequence 2:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster

Alignment Length:	793	Identity:	166/793 - (20%)
Similarity:	281/793 - (35%)	Gaps:	236/793 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   128 SIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISW 192
            |||:.....|:...:|..:..|:|:         |.:..:.||.||:..|..|.||.|.|...||
  Fly   432 SIGSCFSTSGSLNNSLKPVEKIVLK---------ENTPGQDLLEWCKEVTKDYPNVKVTNLTTSW 487

Human   193 KDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAI 257
            ::|:||.|:||...||||:..||...|.|.|....|:.||. |.||::::..|:.....||:.|:
  Fly   488 RNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAES-LGIPRVIEPRDMNMLTVPDKLAV 551

Human   258 MTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQ 322
            |||:......|:|.|.      :|.::.:...|:.:::.||:                 .|.:.|
  Fly   552 MTYLHQLRAHFTGKQL------KIEQIGSTADESSYVIGDYK-----------------SDNLSQ 593

Human   323 KTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNR-PAFMPSEGKMVSDI--- 383
            ..|.....|                    .|.::.|:...::..||: ....|:..|.|.::
  Fly   594 NRINFSHPK--------------------SLLLHQNSFDEEINGSNKSEQLSPTSKKDVKNLILY 638

Human   384 ------------------NNGWQHLEQA---------------EKGYEEWLLNEIRRLERLD-HL 414
                              .|..||..|:               :||.:.. ..|...:..:| ..
  Fly   639 NSKNILDKVLSPTKDKNSINASQHANQSPMLSCQTTPPQDESLDKGSQPG-GKENSSITTIDPQA 702

Human   415 AEKFRQKASIHEAWTDGKEAMLKHR-----DYETATLSDIKALIRK-HEAFESDLAAHQDRVE-- 471
            |.:.||:..:.:|    :..:|:.|     ..|:.|...::..|.. |...|...|.|..::|
  Fly   703 ASEERQQRLLEQA----RRLILETRVKSGGSIESPTRPKLERTISPIHNGAEEFYAEHAKKLELK 763

Human   472 QIAAIAQELNELDYYDSHN-----VNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQ--L 529
            :..:.:..|::.....|.|     |:.:.:|..|:...:.|       .||..|::.|||||  .
  Fly   764 EPGSPSHRLSDPKVLQSFNAIVERVSPKHEKRGDKLSYIDS-------ELEALEREQEAIDQKAS 821

Human   530 HLEYAKRAA----PFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADRE------- 583
            :||...||.    |.||....|..  .:.|    :..|...|...|..:..|.|:|.|
  Fly   822 NLEAKLRAVMGGNPSNNRRGGARN--SNPF----LRLIRNSIGGGDVIRIKLLDSDDESLFGGGA 880

Human   584 -----REAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQ------IINSKWEK------------ 625
                 |..  |..::..|...|:.:..||...:|.:.|:      .:|...:.
  Fly   881 GSGGGRSG--ACSEDDDRDTSSDSVCNSGDELHTRLRPRPRSHSCFVNKNHQSTINTPAHLRPHH 943

Human   626 VQQLVP------KRDHALLEEQS--------------------------KQQSNEHLRRQ----- 653
            |..:||      ....||..:||                          ::|.:.|.||:
  Fly   944 VHHVVPYTHMLDSSPSALSSQQSSCDNLPACSDDDEVLAVAANGRAASLRRQQDRHRRRRQRRER 1008

Human   654 -------------FASQANVVGPW--IQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPN 703
                         ..::..::..|  :..|...:.|..:::| .||.:    |..||...
  Fly  1009 RSHLCHTPNHCETEETEEQLLSQWFTLVNKKNALLRRQMQLN-ILEQE----KDLERKYT----- 1063

Human   704 LDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIAR---TINEVENQILTRDAKGISQE 765
              :|.|:.:..|.  :.|.:.|....|..|:..|:|:|.:.:   .:..:.||       .|:.|
  Fly  1064 --MLNQELRAAQS--VEDWRKTEVQREKERLLLEELMTIVDKRDQLVQHLHNQ-------EIAIE 1117

Human   766 QMQEFRASFNHFD 778
            ..||......|.|
  Fly  1118 DDQEIARKLEHVD 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACTN4	XP_016882820.1	CH_ACTN_rpt1	47..151	CDD:409063	6/22 (27%)
		CH_ACTN_rpt2	155..269	CDD:409065	41/113 (36%)
		SPEC	296..517	CDD:238103	42/271 (15%)
		SPEC	414..640	CDD:238103	59/280 (21%)
		SPEC	532..754	CDD:238103	55/310 (18%)
		PTZ00184	759..>890	CDD:185504	6/20 (30%)
		EFhand_Ca_insen	863..929	CDD:400872
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	40/102 (39%)
		DUF3585	<1027..1122	CDD:288945	24/115 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0035
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810