Protein Alignment ACTN4 and actn4

DIOPT Version :10

• Sequence 1: NP_001427225.1
• Gene: ACTN4 / 81
• HGNCID: 166
• Length: 933
• Species: Homo sapiens
• Sequence 2: XP_021337011.1
• Gene: actn4 / 322221
• ZFINID: ZDB-GENE-030131-940
• Length: 923
• Species: Danio rerio
• Alignment Length: 933
• Identity: 808/933 - (86%)
• Similarity: 868/933 - (93%)
• Gaps: 10/933 - (1%)

Human     1 MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLR 65
            ||||||.|...||       .|||..:   ||.||:|||||||||||||||||||||||||||||
Zfish     1 MVDYHAVNNQGQY-------SAGGPPT---YMEQENDWDRDLLLDPAWEKQQRKTFTAWCNSHLR 55

Human    66 KAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIG 130
            |||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish    56 KAGTQIENIEEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIG 120

Human   131 AEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDG 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   121 AEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDG 185

Human   196 LAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTY 260
            |||||||||||||||:|||||||||||||||||||||:|||||||||||||||||||||||||||
Zfish   186 LAFNALIHRHRPELIDYDKLRKDDPVTNLNNAFEVAERYLDIPKMLDAEDIVNTARPDEKAIMTY 250

Human   261 VSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTI 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|.|:||:
Zfish   251 VSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLENRAPEKTM 315

Human   326 QEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHL 390
            .|||||||||||||||||||||||||||||||||||||||||||||||||||:||||||..|..|
Zfish   316 AEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINGAWHKL 380

Human   391 EQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRK 455
            |.||||||||||||||||||||||||||||||:|||.|||||||||..:|||||:||:||||::|
Zfish   381 EGAEKGYEEWLLNEIRRLERLDHLAEKFRQKAAIHEGWTDGKEAMLTQKDYETASLSEIKALLKK 445

Human   456 HEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTE 520
            |||||||||||||||||||||||||||||||||.:||.||||||:|||||||||.:|||:||:||
Zfish   446 HEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICEQWDALGSLTQNRRESLERTE 510

Human   521 KQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADRERE 585
            ||||:||:|:|||||||||||||||.||||||||||||.|:||:|||:||:|||||||:|::|||
Zfish   511 KQLESIDELYLEYAKRAAPFNNWMEGAMEDLQDMFIVHNIDEIQGLITAHEQFKSTLPEANKERE 575

Human   586 AILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHL 650
            ||.||..|.|:||..|.|||:|:|||||:|||.|:.||||||||||:||.||.||.::||||:||
Zfish   576 AIQAIQAEVQKIANYNGIKLAGNNPYTTITPQSIDKKWEKVQQLVPQRDQALQEELTRQQSNDHL 640

Human   651 RRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQ 715
            |||||:|||::|||||.||||||||||||||||||||:||.|||:||::||||:|.||..|||||
Zfish   641 RRQFANQANMIGPWIQNKMEEIGRISIEMNGTLEDQLTHLSQYEQSIIEYKPNIDQLEGDHQLIQ 705

Human   716 EALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKD 780
            ||||||||:|.|||||:|||||||||||||||||:|||:||||||||||||:.|:|.||||||||
Zfish   706 EALIFDNKYTAYTMEHLRVGWEQLLTTIARTINEIENQVLTRDAKGISQEQLHEYRTSFNHFDKD 770

Human   781 HGGALGPEEFKACLISLGYDVENDRQKQTGSMDSDDFRALLISTGYSLGEAEFNRIMSLVDPNHS 845
            |.|.|..|||||||||||||||||:||:||.||||||||||||||.|||:|||.|||.:||||:|
Zfish   771 HSGLLQSEEFKACLISLGYDVENDKQKRTGIMDSDDFRALLISTGNSLGDAEFARIMGIVDPNNS 835

Human   846 GLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQG 910
            |.||||||||||||||||||||||||||||:||||||:|||||||||||||||||||||||||.|
Zfish   836 GAVTFQAFIDFMSRETTDTDTADQVIASFKILAGDKNYITAEELRRELPPDQAEYCIARMAPYSG 900

Human   911 PDAVPGALDYKSFSTALYGESDL 933
            ||||.|||||.||||||||||||
Zfish   901 PDAVAGALDYMSFSTALYGESDL 923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACTN4	NP_001427225.1	None
actn4	XP_021337011.1	CH_ACTN_rpt1	37..141	CDD:409063	102/103 (99%)
		CH_ACTN_rpt2	145..259	CDD:409065	111/113 (98%)
		Spectrin	283..393	CDD:395348	98/109 (90%)
		SPEC	404..631	CDD:238103	180/226 (80%)
		Spectrin	639..742	CDD:395348	85/102 (83%)
		PTZ00184	749..>880	CDD:185504	110/130 (85%)
		EFhand_Ca_insen	853..919	CDD:430177	60/65 (92%)