Protein Alignment ACTN4 and ain1

DIOPT Version :10

• Sequence 1: NP_001427225.1
• Gene: ACTN4 / 81
• HGNCID: 166
• Length: 933
• Species: Homo sapiens
• Sequence 2: NP_594295.1
• Gene: ain1 / 2542805
• PomBaseID: SPAC15A10.08
• Length: 621
• Species: Schizosaccharomyces pombe
• Alignment Length: 889
• Identity: 226/889 - (25%)
• Similarity: 351/889 - (39%)
• Gaps: 284/889 - (31%)

Human    48 WEKQQRKTFTAWCNSHLRKAG-TQIENIDEDFRDGLKLMLLLEVISGERLPKPERG-KMRVHKIN 110
            |:..|.:|||.|.|:.|.... ..:.::.:|..||:.|:.|||:|..|.|.:..|. :||||::.
pombe     6 WQSVQNRTFTKWFNTKLSSRDLPSVFDLRKDLSDGILLIQLLEIIGDENLGRYNRNPRMRVHRLE 70

Human   111 NVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQR 175
            ||||||::|.|||:.|.:||..:|||||.|:.||:|||:||||.|.||:.|..:|||||||||||
pombe    71 NVNKALEYIKSKGMPLTNIGPADIVDGNLKLILGLIWTLILRFTIADINEEGLTAKEGLLLWCQR 135

Human   176 KTAPY-KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPK 239
            |||.| ..|:||:|..||.:||||.||||:|||:|::|:||.|.:...|:..||::|:|.:.||:
pombe   136 KTANYHPEVDVQDFTRSWTNGLAFCALIHQHRPDLLDYNKLDKKNHRANMQLAFDIAQKSIGIPR 200

Human   240 MLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASD 304
            :::.||:.:..||||::|||||:.::||||...|.||||.|:.:...|......:..|||.....
pombe   201 LIEVEDVCDVDRPDERSIMTYVAEYFHAFSTLDKVETAARRVERFTEVLMSTHDMKIDYESRMKR 265

Human   305 LLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNR 369
            ||..|.|...:......:....:::....:|..::...|...|:||..||....|:||.|:....
pombe   266 LLGSIARMQEYWHTVQFENNYTDVKSHSNNFAKFKATEKREWVKEKIDLESLLGTIQTNLKTYQL 330

Human   370 PAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEA 434
            ..:.|..|..:.|:...|:                       |.|:|
pombe   331 RKYEPPAGLKIVDLERQWK-----------------------DFLSE------------------ 354

Human   435 MLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKIC 499
                                  ||.:|.|                           :||..::|
pombe   355 ----------------------EANQSKL---------------------------INTHMREI- 369

Human   500 DQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIE 564
                                                                             
pombe   370 ----------------------------------------------------------------- 369

Human   565 GLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQL 629
                                       ||:.|||
pombe   370 ---------------------------KESMRIA------------------------------- 376

Human   630 VPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYE 694
                                    ||.:||.....:.|...||    ..:.|...|||.|::..:
pombe   377 ------------------------FADRANSFSKMLSTISNEI----TNLQGDWRDQLDHVEFLQ 413

Human   695 RSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDA 759
            ..:...:..|..::..:....:|.|.:|.:|.::.|.:...:......||..|..:||::|.|:.
pombe   414 EHLGPLEVELASVKVLYDNCFQAGIEENDYTMFSYEDLEHEFGITANIIANKIKYLENELLEREK 478

Human   760 KGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLG--YDVENDRQKQTGSMDSDDFRALLI 822
            :.:|::::......|.||:|.....|...||.|.|.|||  ||.|.
pombe   479 RTLSKQELDGITKVFRHFEKKKSNMLNEVEFYAALASLGLVYDTEE------------------- 524

Human   823 STGYSLGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAE 887
                  |.|.|:|.     .|....||::.|.:.:..|..|.|:|.||:.:|..:|..|:::|::
pombe   525 ------GTALFHRA-----ANSEEGVTYERFTEIVMEELEDRDSARQVLYAFCDVADGKSYVTSD 578

Human   888 E-LRRELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYGE 930
            : ||.::.|:..::....|..:.      ..|||.::...|..|
pombe   579 DLLRSQVRPNIVKFLECNMNKHS------EGLDYLTWIKQLLAE 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACTN4	NP_001427225.1	None
ain1	NP_594295.1	SAC6	1..616	CDD:227401	225/887 (25%)