DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ALX1 and Rx

DIOPT Version :9

Sequence 1:	NP_008913.2	Gene:	ALX1 / 8092	HGNCID:	1494	Length:	326	Species:	Homo sapiens
Sequence 2:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	408	Identity:	101/408 - (24%)
Similarity:	145/408 - (35%)	Gaps:	163/408 - (39%)

- Green bases have known domain annotations that are detailed below.

Human    66 ERTSPCQDSSVNYGITKVEGQPLHTELNRAMDNCNSLRMSPVKGMQEKGELDELGDKCDSNVSSS 130
            ||.:...||.||......|      :||:.  |.:........|..::|:        |.|.:..
  Fly   509 ERLNADSDSLVNGSCASSE------DLNQT--NSSEQGEKITSGSDDEGQ--------DDNCAKK 557

Human   131 KKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERYGQ 195
            |.||:|||||:.||.|||:.|:|:||||||.||:||::..|.|.||||||||||||||::|:...
  Fly   558 KHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSES 622

Human   196 IQQAKSHFAATYD-------------------ISVLPRTDSYPQI--------QNNLWAGNASGG 233
            ::...:||.....                   :|.||...|:||.        ..:|..||.:..
  Fly   623 LRLGLTHFTQLPHRLGCGASGLPVDPWLSPPLLSALPGFLSHPQTVYPSYLTPPLSLAPGNLTMS 687

Human   234 SVVT-----------------------------------------------------SCMLPRDT 245
            |:..                                                     |.|.|..|
  Fly   688 SLAAMGHHHAHNGPPPPHVGHGGHGQPQPPPPPPPHGVPHPHGSHHVVPLSHLSPHLSRMSPHAT 752

Human   246 S-----SCMTPYS---HS---PRTDSSYTGFSNHQNQFSHVPL---------------------- 277
            |     ..:||..   ||   |.:.::....|:.|:..|...|
  Fly   753 SLGSPHHGVTPLGTPLHSSLPPSSTATTVAVSSSQSSSSSASLECSGPDVCMSPQNLSIGNADSN 817

Human   278 --NNFFTDSLLTGATN---GHAFE-----------------------------TKPEFERRSSSI 308
              ....:..|..|:|:   |.:.:                             :.|..:.||:||
  Fly   818 GDGRDLSSDLDAGSTSSNPGSSLDKCAASANIELLDVGRDSPPPPPTPTGKGSSTPPTDMRSNSI 882

Human   309 AVLRMKAKEHTANISWAM 326
            |.||:|||||..|::..|
  Fly   883 ATLRIKAKEHLDNLNKGM 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALX1	NP_008913.2	Homeobox	135..189	CDD:365835	37/53 (70%)
		Transactivation domain. /evidence=ECO:0000250\|UniProtKB:Q63087	192..326		44/280 (16%)
		OAR	302..320	CDD:367680	12/17 (71%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	306..319		9/12 (75%)
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	36/51 (71%)
Rx	NP_726006.3	OAR	876..892	CDD:281777	10/15 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920